The hypoxic tumor microenvironment and drug resistance against EGFR inhibitors: preclinical study in cetuximab-sensitive head and neck squamous cell carcinoma cell lines

BACKGROUND: Increased expression of the epidermal growth factor receptor (EGFR) is observed in more than 90% of all head and neck squamous cell carcinomas (HNSCC). Therefore, EGFR has emerged as a promising therapeutic target. Nevertheless, drug resistance remains a major challenge and an important...

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Detalles Bibliográficos
Autores principales: Boeckx, Carolien, Van den Bossche, Jolien, De Pauw, Ines, Peeters, Marc, Lardon, Filip, Baay, Marc, Wouters, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467624/
https://www.ncbi.nlm.nih.gov/pubmed/26032726
http://dx.doi.org/10.1186/s13104-015-1197-6

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