Targeted inhibition of the Shroom3–Rho kinase protein–protein interaction circumvents Nogo66 to promote axon outgrowth

BACKGROUND: Inhibitory molecules in the adult central nervous system, including NogoA, impede neural repair by blocking axon outgrowth. The actin-myosin regulatory protein Shroom3 directly interacts with Rho kinase and conveys axon outgrowth inhibitory signals from Nogo66, a C-terminal inhibitory do...

Descripción completa

Detalles Bibliográficos
Autores principales: Dickson, Heather M, Wilbur, Amanda, Reinke, Ashley A, Young, Mathew A, Vojtek, Anne B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467669/
https://www.ncbi.nlm.nih.gov/pubmed/26077244
http://dx.doi.org/10.1186/s12868-015-0171-5

Ejemplares similares

Ejemplares similares