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Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion

PURPOSE: To investigate the ocular neovascularization (ONV) rate in eyes with a branch retinal artery occlusion (BRAO) or a central retinal artery occlusion (CRAO), and to study factors that may influence the ONV rate secondary to CRAO. METHODS: This was a retrospective case series of consecutive pa...

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Autores principales: Mason, John O, Patel, Shyam A, Feist, Richard M, Albert, Michael A, Huisingh, Carrie, McGwin, Gerald, Thomley, Martin L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467756/
https://www.ncbi.nlm.nih.gov/pubmed/26089631
http://dx.doi.org/10.2147/OPTH.S82796
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author Mason, John O
Patel, Shyam A
Feist, Richard M
Albert, Michael A
Huisingh, Carrie
McGwin, Gerald
Thomley, Martin L
author_facet Mason, John O
Patel, Shyam A
Feist, Richard M
Albert, Michael A
Huisingh, Carrie
McGwin, Gerald
Thomley, Martin L
author_sort Mason, John O
collection PubMed
description PURPOSE: To investigate the ocular neovascularization (ONV) rate in eyes with a branch retinal artery occlusion (BRAO) or a central retinal artery occlusion (CRAO), and to study factors that may influence the ONV rate secondary to CRAO. METHODS: This was a retrospective case series of consecutive patients (286 total eyes: 83 CRAOs and 203 BRAOs) who were diagnosed with a retinal artery occlusion from 1998 to 2013 at the Retina Consultants of Alabama and University of Alabama at Birmingham, Birmingham, AL, USA. Generalized estimating equations were used to evaluate the association between hypothesized risk factors and ONV development. RESULTS: Twelve (14.5%) of the 83 eyes with a CRAO developed ONV. Eleven of 12 eyes (91.7%) had iris neovascularization, ten of 12 eyes (83.3%) had neovascular glaucoma, and two of 12 eyes (16.7%) had neovascularization of the optic disc. The average time for ONV development secondary to CRAO was 30.7 days, ranging from the date of presentation to 137 days. Only two (<1.0%) of the 203 eyes with a BRAO developed iris neovascularization. Diabetes mellitus type 2 was a risk factor for ONV development following a CRAO with an adjusted odds ratio of 5.2 (95% confidence interval: 1.4–19.8) (P=0.02). CONCLUSION: ONV is an important complication of CRAO and is a less-frequent complication of BRAO. Patients with a CRAO, especially those with diabetes mellitus type 2, should be closely monitored for the first 6 months for ONV.
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spelling pubmed-44677562015-06-18 Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion Mason, John O Patel, Shyam A Feist, Richard M Albert, Michael A Huisingh, Carrie McGwin, Gerald Thomley, Martin L Clin Ophthalmol Original Research PURPOSE: To investigate the ocular neovascularization (ONV) rate in eyes with a branch retinal artery occlusion (BRAO) or a central retinal artery occlusion (CRAO), and to study factors that may influence the ONV rate secondary to CRAO. METHODS: This was a retrospective case series of consecutive patients (286 total eyes: 83 CRAOs and 203 BRAOs) who were diagnosed with a retinal artery occlusion from 1998 to 2013 at the Retina Consultants of Alabama and University of Alabama at Birmingham, Birmingham, AL, USA. Generalized estimating equations were used to evaluate the association between hypothesized risk factors and ONV development. RESULTS: Twelve (14.5%) of the 83 eyes with a CRAO developed ONV. Eleven of 12 eyes (91.7%) had iris neovascularization, ten of 12 eyes (83.3%) had neovascular glaucoma, and two of 12 eyes (16.7%) had neovascularization of the optic disc. The average time for ONV development secondary to CRAO was 30.7 days, ranging from the date of presentation to 137 days. Only two (<1.0%) of the 203 eyes with a BRAO developed iris neovascularization. Diabetes mellitus type 2 was a risk factor for ONV development following a CRAO with an adjusted odds ratio of 5.2 (95% confidence interval: 1.4–19.8) (P=0.02). CONCLUSION: ONV is an important complication of CRAO and is a less-frequent complication of BRAO. Patients with a CRAO, especially those with diabetes mellitus type 2, should be closely monitored for the first 6 months for ONV. Dove Medical Press 2015-06-05 /pmc/articles/PMC4467756/ /pubmed/26089631 http://dx.doi.org/10.2147/OPTH.S82796 Text en © 2015 Mason et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Mason, John O
Patel, Shyam A
Feist, Richard M
Albert, Michael A
Huisingh, Carrie
McGwin, Gerald
Thomley, Martin L
Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
title Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
title_full Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
title_fullStr Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
title_full_unstemmed Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
title_short Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
title_sort ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467756/
https://www.ncbi.nlm.nih.gov/pubmed/26089631
http://dx.doi.org/10.2147/OPTH.S82796
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