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A P300-based cognitive assessment battery

BACKGROUND: It is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitiv...

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Detalles Bibliográficos
Autores principales: Kirschner, Aaron, Cruse, Damian, Chennu, Srivas, Owen, Adrian M, Hampshire, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467771/
https://www.ncbi.nlm.nih.gov/pubmed/26085962
http://dx.doi.org/10.1002/brb3.336
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author Kirschner, Aaron
Cruse, Damian
Chennu, Srivas
Owen, Adrian M
Hampshire, Adam
author_facet Kirschner, Aaron
Cruse, Damian
Chennu, Srivas
Owen, Adrian M
Hampshire, Adam
author_sort Kirschner, Aaron
collection PubMed
description BACKGROUND: It is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitive processes. METHODS: Here, we develop a series of EEG paradigms that probe several core aspects of cognition at the bedside without the need for motor responses and explore the sensitivity of this approach in a group of healthy controls. RESULTS: Using analysis of ERPs alone, this method can determine with high reliability whether individual participants are able to attend a stimulus stream, maintain items in working memory, or solve complex grammatical reasoning problems. CONCLUSION: We suggest that this approach could form the basis of a brain-based battery for assessing higher cognition in patients with severe motor impairments or disorders of consciousness.
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spelling pubmed-44677712015-06-17 A P300-based cognitive assessment battery Kirschner, Aaron Cruse, Damian Chennu, Srivas Owen, Adrian M Hampshire, Adam Brain Behav Original Research BACKGROUND: It is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitive processes. METHODS: Here, we develop a series of EEG paradigms that probe several core aspects of cognition at the bedside without the need for motor responses and explore the sensitivity of this approach in a group of healthy controls. RESULTS: Using analysis of ERPs alone, this method can determine with high reliability whether individual participants are able to attend a stimulus stream, maintain items in working memory, or solve complex grammatical reasoning problems. CONCLUSION: We suggest that this approach could form the basis of a brain-based battery for assessing higher cognition in patients with severe motor impairments or disorders of consciousness. BlackWell Publishing Ltd 2015-06 2015-04-23 /pmc/articles/PMC4467771/ /pubmed/26085962 http://dx.doi.org/10.1002/brb3.336 Text en © 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Kirschner, Aaron
Cruse, Damian
Chennu, Srivas
Owen, Adrian M
Hampshire, Adam
A P300-based cognitive assessment battery
title A P300-based cognitive assessment battery
title_full A P300-based cognitive assessment battery
title_fullStr A P300-based cognitive assessment battery
title_full_unstemmed A P300-based cognitive assessment battery
title_short A P300-based cognitive assessment battery
title_sort p300-based cognitive assessment battery
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467771/
https://www.ncbi.nlm.nih.gov/pubmed/26085962
http://dx.doi.org/10.1002/brb3.336
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