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A P300-based cognitive assessment battery
BACKGROUND: It is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitiv...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467771/ https://www.ncbi.nlm.nih.gov/pubmed/26085962 http://dx.doi.org/10.1002/brb3.336 |
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author | Kirschner, Aaron Cruse, Damian Chennu, Srivas Owen, Adrian M Hampshire, Adam |
author_facet | Kirschner, Aaron Cruse, Damian Chennu, Srivas Owen, Adrian M Hampshire, Adam |
author_sort | Kirschner, Aaron |
collection | PubMed |
description | BACKGROUND: It is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitive processes. METHODS: Here, we develop a series of EEG paradigms that probe several core aspects of cognition at the bedside without the need for motor responses and explore the sensitivity of this approach in a group of healthy controls. RESULTS: Using analysis of ERPs alone, this method can determine with high reliability whether individual participants are able to attend a stimulus stream, maintain items in working memory, or solve complex grammatical reasoning problems. CONCLUSION: We suggest that this approach could form the basis of a brain-based battery for assessing higher cognition in patients with severe motor impairments or disorders of consciousness. |
format | Online Article Text |
id | pubmed-4467771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44677712015-06-17 A P300-based cognitive assessment battery Kirschner, Aaron Cruse, Damian Chennu, Srivas Owen, Adrian M Hampshire, Adam Brain Behav Original Research BACKGROUND: It is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitive processes. METHODS: Here, we develop a series of EEG paradigms that probe several core aspects of cognition at the bedside without the need for motor responses and explore the sensitivity of this approach in a group of healthy controls. RESULTS: Using analysis of ERPs alone, this method can determine with high reliability whether individual participants are able to attend a stimulus stream, maintain items in working memory, or solve complex grammatical reasoning problems. CONCLUSION: We suggest that this approach could form the basis of a brain-based battery for assessing higher cognition in patients with severe motor impairments or disorders of consciousness. BlackWell Publishing Ltd 2015-06 2015-04-23 /pmc/articles/PMC4467771/ /pubmed/26085962 http://dx.doi.org/10.1002/brb3.336 Text en © 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Kirschner, Aaron Cruse, Damian Chennu, Srivas Owen, Adrian M Hampshire, Adam A P300-based cognitive assessment battery |
title | A P300-based cognitive assessment battery |
title_full | A P300-based cognitive assessment battery |
title_fullStr | A P300-based cognitive assessment battery |
title_full_unstemmed | A P300-based cognitive assessment battery |
title_short | A P300-based cognitive assessment battery |
title_sort | p300-based cognitive assessment battery |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467771/ https://www.ncbi.nlm.nih.gov/pubmed/26085962 http://dx.doi.org/10.1002/brb3.336 |
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