Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap

TCF21 is a basic helix–loop–helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated target genes in a major disease relevant cell type, we perfo...

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Detalles Bibliográficos
Autores principales: Nurnberg, S.T., Cheng, K., Raiesdana, A., Kundu, R., Miller, C.L., Kim, J.B., Arora, K., Carcamo-Oribe, I., Xiong, Y., Tellakula, N., Nanda, V., Murthy, N., Boisvert, W.A., Hedin, U., Perisic, L., Aldi, S., Maegdefessel, L., Pjanic, M., Owens, G.K., Tallquist, M.D., Quertermous, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data in Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467834/
https://www.ncbi.nlm.nih.gov/pubmed/26090325
http://dx.doi.org/10.1016/j.gdata.2015.05.007
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author Nurnberg, S.T.
Cheng, K.
Raiesdana, A.
Kundu, R.
Miller, C.L.
Kim, J.B.
Arora, K.
Carcamo-Oribe, I.
Xiong, Y.
Tellakula, N.
Nanda, V.
Murthy, N.
Boisvert, W.A.
Hedin, U.
Perisic, L.
Aldi, S.
Maegdefessel, L.
Pjanic, M.
Owens, G.K.
Tallquist, M.D.
Quertermous, T.
author_facet Nurnberg, S.T.
Cheng, K.
Raiesdana, A.
Kundu, R.
Miller, C.L.
Kim, J.B.
Arora, K.
Carcamo-Oribe, I.
Xiong, Y.
Tellakula, N.
Nanda, V.
Murthy, N.
Boisvert, W.A.
Hedin, U.
Perisic, L.
Aldi, S.
Maegdefessel, L.
Pjanic, M.
Owens, G.K.
Tallquist, M.D.
Quertermous, T.
author_sort Nurnberg, S.T.
collection PubMed
description TCF21 is a basic helix–loop–helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated target genes in a major disease relevant cell type, we performed siRNA knockdown of TCF21 in in vitro cultured human coronary artery smooth muscle cells and compared the transcriptome of siTCF21 versus siCONTROL treated cells. The raw (FASTQ) as well as processed (BED) data from 3 technical replicates per treatment has been deposited with Gene Expression Omnibus (GSE44461).
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spelling pubmed-44678342015-10-19 Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap Nurnberg, S.T. Cheng, K. Raiesdana, A. Kundu, R. Miller, C.L. Kim, J.B. Arora, K. Carcamo-Oribe, I. Xiong, Y. Tellakula, N. Nanda, V. Murthy, N. Boisvert, W.A. Hedin, U. Perisic, L. Aldi, S. Maegdefessel, L. Pjanic, M. Owens, G.K. Tallquist, M.D. Quertermous, T. Genom Data Data in Brief TCF21 is a basic helix–loop–helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated target genes in a major disease relevant cell type, we performed siRNA knockdown of TCF21 in in vitro cultured human coronary artery smooth muscle cells and compared the transcriptome of siTCF21 versus siCONTROL treated cells. The raw (FASTQ) as well as processed (BED) data from 3 technical replicates per treatment has been deposited with Gene Expression Omnibus (GSE44461). Elsevier 2015-05-17 /pmc/articles/PMC4467834/ /pubmed/26090325 http://dx.doi.org/10.1016/j.gdata.2015.05.007 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Data in Brief
Nurnberg, S.T.
Cheng, K.
Raiesdana, A.
Kundu, R.
Miller, C.L.
Kim, J.B.
Arora, K.
Carcamo-Oribe, I.
Xiong, Y.
Tellakula, N.
Nanda, V.
Murthy, N.
Boisvert, W.A.
Hedin, U.
Perisic, L.
Aldi, S.
Maegdefessel, L.
Pjanic, M.
Owens, G.K.
Tallquist, M.D.
Quertermous, T.
Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap
title Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap
title_full Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap
title_fullStr Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap
title_full_unstemmed Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap
title_short Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap
title_sort coronary artery disease associated transcription factor tcf21 regulates smooth muscle precursor cells that contribute to the fibrous cap
topic Data in Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467834/
https://www.ncbi.nlm.nih.gov/pubmed/26090325
http://dx.doi.org/10.1016/j.gdata.2015.05.007
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