TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response

A high throughput screen for compounds that induce TRAIL-mediated apoptosis identified ML100 as an active chemical probe, which potentiated TRAIL activity in prostate carcinoma PPC-1 and melanoma MDA-MB-435 cells. Follow-up in silico modeling and profiling in cell-based assays allowed us to identify...

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Detalles Bibliográficos
Autores principales: Rozanov, Dmitri, Cheltsov, Anton, Sergienko, Eduard, Vasile, Stefan, Golubkov, Vladislav, Aleshin, Alexander E., Levin, Trevor, Traer, Elie, Hann, Byron, Freimuth, Julia, Alexeev, Nikita, Alekseyev, Max A., Budko, Sergey P, Bächinger, Hans Peter, Spellman, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468210/
https://www.ncbi.nlm.nih.gov/pubmed/26075913
http://dx.doi.org/10.1371/journal.pone.0129566

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