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Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression
Introduction. A possible association between olfactory dysfunction and Parkinson's disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation. Methods....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468273/ https://www.ncbi.nlm.nih.gov/pubmed/26136625 http://dx.doi.org/10.1155/2015/976589 |
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author | Cavaco, Sara Gonçalves, Alexandra Mendes, Alexandre Vila-Chã, Nuno Moreira, Inês Fernandes, Joana Damásio, Joana Teixeira-Pinto, Armando Bastos Lima, António |
author_facet | Cavaco, Sara Gonçalves, Alexandra Mendes, Alexandre Vila-Chã, Nuno Moreira, Inês Fernandes, Joana Damásio, Joana Teixeira-Pinto, Armando Bastos Lima, António |
author_sort | Cavaco, Sara |
collection | PubMed |
description | Introduction. A possible association between olfactory dysfunction and Parkinson's disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation. Methods. One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i.e., 80% specificity) were considered demographically abnormal. Patients underwent motor examination after 12 h without antiparkinsonian medication. Results. Eighty-two percent of PD patients had abnormal olfaction. Abnormal performance on the Brief-Smell Identification Test was associated with higher disease severity (i.e., Hoehn and Yahr, Unified Parkinson's Disease Rating Scale-III, Freezing of Gait questionnaire, and levodopa equivalent dose), even when disease duration was taken into account. Conclusions. Abnormal olfaction in PD is associated with increased severity and faster disease progression. |
format | Online Article Text |
id | pubmed-4468273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44682732015-07-01 Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression Cavaco, Sara Gonçalves, Alexandra Mendes, Alexandre Vila-Chã, Nuno Moreira, Inês Fernandes, Joana Damásio, Joana Teixeira-Pinto, Armando Bastos Lima, António Behav Neurol Research Article Introduction. A possible association between olfactory dysfunction and Parkinson's disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation. Methods. One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i.e., 80% specificity) were considered demographically abnormal. Patients underwent motor examination after 12 h without antiparkinsonian medication. Results. Eighty-two percent of PD patients had abnormal olfaction. Abnormal performance on the Brief-Smell Identification Test was associated with higher disease severity (i.e., Hoehn and Yahr, Unified Parkinson's Disease Rating Scale-III, Freezing of Gait questionnaire, and levodopa equivalent dose), even when disease duration was taken into account. Conclusions. Abnormal olfaction in PD is associated with increased severity and faster disease progression. Hindawi Publishing Corporation 2015 2015-06-02 /pmc/articles/PMC4468273/ /pubmed/26136625 http://dx.doi.org/10.1155/2015/976589 Text en Copyright © 2015 Sara Cavaco et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cavaco, Sara Gonçalves, Alexandra Mendes, Alexandre Vila-Chã, Nuno Moreira, Inês Fernandes, Joana Damásio, Joana Teixeira-Pinto, Armando Bastos Lima, António Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression |
title | Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression |
title_full | Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression |
title_fullStr | Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression |
title_full_unstemmed | Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression |
title_short | Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression |
title_sort | abnormal olfaction in parkinson's disease is related to faster disease progression |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468273/ https://www.ncbi.nlm.nih.gov/pubmed/26136625 http://dx.doi.org/10.1155/2015/976589 |
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