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Stem Cells for Cutaneous Wound Healing

Optimum healing of a cutaneous wound involves a well-orchestrated cascade of biological and molecular processes involving cell migration, proliferation, extracellular matrix deposition, and remodelling. When the normal biological process fails for any reason, this healing process can stall resulting...

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Detalles Bibliográficos
Autores principales: Kirby, Giles T. S., Mills, Stuart J., Cowin, Allison J., Smith, Louise E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468276/
https://www.ncbi.nlm.nih.gov/pubmed/26137471
http://dx.doi.org/10.1155/2015/285869
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author Kirby, Giles T. S.
Mills, Stuart J.
Cowin, Allison J.
Smith, Louise E.
author_facet Kirby, Giles T. S.
Mills, Stuart J.
Cowin, Allison J.
Smith, Louise E.
author_sort Kirby, Giles T. S.
collection PubMed
description Optimum healing of a cutaneous wound involves a well-orchestrated cascade of biological and molecular processes involving cell migration, proliferation, extracellular matrix deposition, and remodelling. When the normal biological process fails for any reason, this healing process can stall resulting in chronic wounds. Wounds are a growing clinical burden on healthcare systems and with an aging population as well as increasing incidences of obesity and diabetes, this problem is set to increase. Cell therapies may be the solution. A range of cell based approaches have begun to cross the rift from bench to bedside and the supporting data suggests that the appropriate administration of stem cells can accelerate wound healing. This review examines the main cell types explored for cutaneous wound healing with a focus on clinical use. The literature overwhelmingly suggests that cell therapies can help to heal cutaneous wounds when used appropriately but we are at risk of clinical use outpacing the evidence. There is a need, now more than ever, for standardised methods of cell characterisation and delivery, as well as randomised clinical trials.
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spelling pubmed-44682762015-07-01 Stem Cells for Cutaneous Wound Healing Kirby, Giles T. S. Mills, Stuart J. Cowin, Allison J. Smith, Louise E. Biomed Res Int Review Article Optimum healing of a cutaneous wound involves a well-orchestrated cascade of biological and molecular processes involving cell migration, proliferation, extracellular matrix deposition, and remodelling. When the normal biological process fails for any reason, this healing process can stall resulting in chronic wounds. Wounds are a growing clinical burden on healthcare systems and with an aging population as well as increasing incidences of obesity and diabetes, this problem is set to increase. Cell therapies may be the solution. A range of cell based approaches have begun to cross the rift from bench to bedside and the supporting data suggests that the appropriate administration of stem cells can accelerate wound healing. This review examines the main cell types explored for cutaneous wound healing with a focus on clinical use. The literature overwhelmingly suggests that cell therapies can help to heal cutaneous wounds when used appropriately but we are at risk of clinical use outpacing the evidence. There is a need, now more than ever, for standardised methods of cell characterisation and delivery, as well as randomised clinical trials. Hindawi Publishing Corporation 2015 2015-06-02 /pmc/articles/PMC4468276/ /pubmed/26137471 http://dx.doi.org/10.1155/2015/285869 Text en Copyright © 2015 Giles T. S. Kirby et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kirby, Giles T. S.
Mills, Stuart J.
Cowin, Allison J.
Smith, Louise E.
Stem Cells for Cutaneous Wound Healing
title Stem Cells for Cutaneous Wound Healing
title_full Stem Cells for Cutaneous Wound Healing
title_fullStr Stem Cells for Cutaneous Wound Healing
title_full_unstemmed Stem Cells for Cutaneous Wound Healing
title_short Stem Cells for Cutaneous Wound Healing
title_sort stem cells for cutaneous wound healing
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468276/
https://www.ncbi.nlm.nih.gov/pubmed/26137471
http://dx.doi.org/10.1155/2015/285869
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