TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis

Truncating mutations in the tumor suppressor gene adenomatous polyposis coli (APC) are the initiating step in the vast majority of sporadic colorectal cancers, and they underlie familial adenomatous polyposis (FAP) syndromes. Modeling of APC- driven tumor formation in the mouse has contributed subst...

Descripción completa

Detalles Bibliográficos
Autores principales: Van Nieuwenhuysen, Tom, Naert, Thomas, Tran, Hong Thi, Van Imschoot, Griet, Geurs, Sarah, Sanders, Ellen, Creytens, David, Van Roy, Frans, Vleminckx, Kris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468341/
https://www.ncbi.nlm.nih.gov/pubmed/26097888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468341/
https://www.ncbi.nlm.nih.gov/pubmed/26097888

Ejemplares similares