Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure

Massive hepatic necrosis is a key event underlying acute liver failure, a serious clinical syndrome with high mortality. Massive hepatic necrosis in acute liver failure has unique pathophysiological characteristics including extremely rapid parenchymal cell death and removal. On the other hand, mass...

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Autores principales: Weng, Hong-Lei, Cai, Xiaobo, Yuan, Xiaodong, Liebe, Roman, Dooley, Steven, Li, Hai, Wang, Tai-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468385/
https://www.ncbi.nlm.nih.gov/pubmed/26136687
http://dx.doi.org/10.3389/fphys.2015.00178
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author Weng, Hong-Lei
Cai, Xiaobo
Yuan, Xiaodong
Liebe, Roman
Dooley, Steven
Li, Hai
Wang, Tai-Ling
author_facet Weng, Hong-Lei
Cai, Xiaobo
Yuan, Xiaodong
Liebe, Roman
Dooley, Steven
Li, Hai
Wang, Tai-Ling
author_sort Weng, Hong-Lei
collection PubMed
description Massive hepatic necrosis is a key event underlying acute liver failure, a serious clinical syndrome with high mortality. Massive hepatic necrosis in acute liver failure has unique pathophysiological characteristics including extremely rapid parenchymal cell death and removal. On the other hand, massive necrosis rapidly induces the activation of liver progenitor cells, the so-called “second pathway of liver regeneration.” The final clinical outcome of acute liver failure depends on whether liver progenitor cell-mediated regeneration can efficiently restore parenchymal mass and function within a short time. This review summarizes the current knowledge regarding massive hepatic necrosis and liver progenitor cell-mediated regeneration in patients with acute liver failure, the two sides of one coin.
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spelling pubmed-44683852015-07-01 Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure Weng, Hong-Lei Cai, Xiaobo Yuan, Xiaodong Liebe, Roman Dooley, Steven Li, Hai Wang, Tai-Ling Front Physiol Physiology Massive hepatic necrosis is a key event underlying acute liver failure, a serious clinical syndrome with high mortality. Massive hepatic necrosis in acute liver failure has unique pathophysiological characteristics including extremely rapid parenchymal cell death and removal. On the other hand, massive necrosis rapidly induces the activation of liver progenitor cells, the so-called “second pathway of liver regeneration.” The final clinical outcome of acute liver failure depends on whether liver progenitor cell-mediated regeneration can efficiently restore parenchymal mass and function within a short time. This review summarizes the current knowledge regarding massive hepatic necrosis and liver progenitor cell-mediated regeneration in patients with acute liver failure, the two sides of one coin. Frontiers Media S.A. 2015-06-16 /pmc/articles/PMC4468385/ /pubmed/26136687 http://dx.doi.org/10.3389/fphys.2015.00178 Text en Copyright © 2015 Weng, Cai, Yuan, Liebe, Dooley, Li and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Weng, Hong-Lei
Cai, Xiaobo
Yuan, Xiaodong
Liebe, Roman
Dooley, Steven
Li, Hai
Wang, Tai-Ling
Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure
title Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure
title_full Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure
title_fullStr Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure
title_full_unstemmed Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure
title_short Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure
title_sort two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468385/
https://www.ncbi.nlm.nih.gov/pubmed/26136687
http://dx.doi.org/10.3389/fphys.2015.00178
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