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Fanconi syndrome due to prolonged use of low-dose adefovir

Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus replication but exhibits nephrotoxicity when administered at a low...

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Autores principales: Wang, Xiao-Bing, Zhu, Xiao-Chun, Huang, Xiao-Ying, Ye, Wen-Jing, Wang, Liang-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468461/
https://www.ncbi.nlm.nih.gov/pubmed/26110001
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author Wang, Xiao-Bing
Zhu, Xiao-Chun
Huang, Xiao-Ying
Ye, Wen-Jing
Wang, Liang-Xing
author_facet Wang, Xiao-Bing
Zhu, Xiao-Chun
Huang, Xiao-Ying
Ye, Wen-Jing
Wang, Liang-Xing
author_sort Wang, Xiao-Bing
collection PubMed
description Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus replication but exhibits nephrotoxicity when administered at a low dosage. We report two cases of Fanconi syndrome induced by ADV at 10 mg/day to call for regular screening for evidence of proximal tubular dysfunction and detailed bone metabolic investigations for prompt detection of ADV nephrotoxicity is critically important to ensure timely drug withdrawal before the development of irreversible tubulointerstitial injury.
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spelling pubmed-44684612015-06-24 Fanconi syndrome due to prolonged use of low-dose adefovir Wang, Xiao-Bing Zhu, Xiao-Chun Huang, Xiao-Ying Ye, Wen-Jing Wang, Liang-Xing J Res Med Sci Case Report Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus replication but exhibits nephrotoxicity when administered at a low dosage. We report two cases of Fanconi syndrome induced by ADV at 10 mg/day to call for regular screening for evidence of proximal tubular dysfunction and detailed bone metabolic investigations for prompt detection of ADV nephrotoxicity is critically important to ensure timely drug withdrawal before the development of irreversible tubulointerstitial injury. Medknow Publications & Media Pvt Ltd 2015-04 /pmc/articles/PMC4468461/ /pubmed/26110001 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Wang, Xiao-Bing
Zhu, Xiao-Chun
Huang, Xiao-Ying
Ye, Wen-Jing
Wang, Liang-Xing
Fanconi syndrome due to prolonged use of low-dose adefovir
title Fanconi syndrome due to prolonged use of low-dose adefovir
title_full Fanconi syndrome due to prolonged use of low-dose adefovir
title_fullStr Fanconi syndrome due to prolonged use of low-dose adefovir
title_full_unstemmed Fanconi syndrome due to prolonged use of low-dose adefovir
title_short Fanconi syndrome due to prolonged use of low-dose adefovir
title_sort fanconi syndrome due to prolonged use of low-dose adefovir
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468461/
https://www.ncbi.nlm.nih.gov/pubmed/26110001
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