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Fanconi syndrome due to prolonged use of low-dose adefovir
Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus replication but exhibits nephrotoxicity when administered at a low...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468461/ https://www.ncbi.nlm.nih.gov/pubmed/26110001 |
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author | Wang, Xiao-Bing Zhu, Xiao-Chun Huang, Xiao-Ying Ye, Wen-Jing Wang, Liang-Xing |
author_facet | Wang, Xiao-Bing Zhu, Xiao-Chun Huang, Xiao-Ying Ye, Wen-Jing Wang, Liang-Xing |
author_sort | Wang, Xiao-Bing |
collection | PubMed |
description | Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus replication but exhibits nephrotoxicity when administered at a low dosage. We report two cases of Fanconi syndrome induced by ADV at 10 mg/day to call for regular screening for evidence of proximal tubular dysfunction and detailed bone metabolic investigations for prompt detection of ADV nephrotoxicity is critically important to ensure timely drug withdrawal before the development of irreversible tubulointerstitial injury. |
format | Online Article Text |
id | pubmed-4468461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44684612015-06-24 Fanconi syndrome due to prolonged use of low-dose adefovir Wang, Xiao-Bing Zhu, Xiao-Chun Huang, Xiao-Ying Ye, Wen-Jing Wang, Liang-Xing J Res Med Sci Case Report Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus replication but exhibits nephrotoxicity when administered at a low dosage. We report two cases of Fanconi syndrome induced by ADV at 10 mg/day to call for regular screening for evidence of proximal tubular dysfunction and detailed bone metabolic investigations for prompt detection of ADV nephrotoxicity is critically important to ensure timely drug withdrawal before the development of irreversible tubulointerstitial injury. Medknow Publications & Media Pvt Ltd 2015-04 /pmc/articles/PMC4468461/ /pubmed/26110001 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Wang, Xiao-Bing Zhu, Xiao-Chun Huang, Xiao-Ying Ye, Wen-Jing Wang, Liang-Xing Fanconi syndrome due to prolonged use of low-dose adefovir |
title | Fanconi syndrome due to prolonged use of low-dose adefovir |
title_full | Fanconi syndrome due to prolonged use of low-dose adefovir |
title_fullStr | Fanconi syndrome due to prolonged use of low-dose adefovir |
title_full_unstemmed | Fanconi syndrome due to prolonged use of low-dose adefovir |
title_short | Fanconi syndrome due to prolonged use of low-dose adefovir |
title_sort | fanconi syndrome due to prolonged use of low-dose adefovir |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468461/ https://www.ncbi.nlm.nih.gov/pubmed/26110001 |
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