Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence

The formation of Aβ is directly controlled by the γ-secretase complex and its activator, γ-secretase activating protein (GSAP). GSAP derives from a C-terminal fragment of a larger precursor protein via a caspase-3 mediated cleavage. However, the mechanism regulating this process remains unknown. Her...

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Detalles Bibliográficos
Autores principales: Chu, Jin, Li, Jian-Guo, Hoffman, Nicholas E., Stough, Alexandra M., Madesh, Muniswamy, Praticò, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468577/
https://www.ncbi.nlm.nih.gov/pubmed/26076991
http://dx.doi.org/10.1038/srep11086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468577/
https://www.ncbi.nlm.nih.gov/pubmed/26076991
http://dx.doi.org/10.1038/srep11086

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