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Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder

Abnormal structure and function in the striatum and prefrontal cortex (PFC) have been revealed in Internet addiction disorder (IAD). However, little is known about alterations of corticostriatal functional circuits in IAD. The aim of this study was to investigate the integrity of corticostriatal fun...

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Autores principales: Lin, Fuchun, Zhou, Yan, Du, Yasong, Zhao, Zhimin, Qin, Lindi, Xu, Jianrong, Lei, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468611/
https://www.ncbi.nlm.nih.gov/pubmed/26136677
http://dx.doi.org/10.3389/fnhum.2015.00356
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author Lin, Fuchun
Zhou, Yan
Du, Yasong
Zhao, Zhimin
Qin, Lindi
Xu, Jianrong
Lei, Hao
author_facet Lin, Fuchun
Zhou, Yan
Du, Yasong
Zhao, Zhimin
Qin, Lindi
Xu, Jianrong
Lei, Hao
author_sort Lin, Fuchun
collection PubMed
description Abnormal structure and function in the striatum and prefrontal cortex (PFC) have been revealed in Internet addiction disorder (IAD). However, little is known about alterations of corticostriatal functional circuits in IAD. The aim of this study was to investigate the integrity of corticostriatal functional circuits and their relations to neuropsychological measures in IAD by resting-state functional connectivity (FC). Fourteen IAD adolescents and 15 healthy controls underwent resting-state fMRI scans. Using six predefined bilateral striatal regions-of-interest, voxel-wise correlation maps were computed and compared between groups. Relationships between alterations of corticostriatal connectivity and clinical measurements were examined in the IAD group. Compared to controls, IAD subjects exhibited reduced connectivity between the inferior ventral striatum and bilateral caudate head, subgenual anterior cingulate cortex (ACC), and posterior cingulate cortex, and between the superior ventral striatum and bilateral dorsal/rostral ACC, ventral anterior thalamus, and putamen/pallidum/insula/inferior frontal gyrus (IFG), and between the dorsal caudate and dorsal/rostral ACC, thalamus, and IFG, and between the left ventral rostral putamen and right IFG. IAD subjects also showed increased connectivity between the left dorsal caudal putamen and bilateral caudal cigulate motor area. Moreover, altered cotricostriatal functional circuits were significantly correlated with neuropsychological measures. This study directly provides evidence that IAD is associated with alterations of corticostriatal functional circuits involved in the affective and motivation processing, and cognitive control. These findings emphasize that functional connections in the corticostriatal circuits are modulated by affective/motivational/cognitive states and further suggest that IAD may have abnormalities of such modulation in this network.
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spelling pubmed-44686112015-07-01 Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder Lin, Fuchun Zhou, Yan Du, Yasong Zhao, Zhimin Qin, Lindi Xu, Jianrong Lei, Hao Front Hum Neurosci Neuroscience Abnormal structure and function in the striatum and prefrontal cortex (PFC) have been revealed in Internet addiction disorder (IAD). However, little is known about alterations of corticostriatal functional circuits in IAD. The aim of this study was to investigate the integrity of corticostriatal functional circuits and their relations to neuropsychological measures in IAD by resting-state functional connectivity (FC). Fourteen IAD adolescents and 15 healthy controls underwent resting-state fMRI scans. Using six predefined bilateral striatal regions-of-interest, voxel-wise correlation maps were computed and compared between groups. Relationships between alterations of corticostriatal connectivity and clinical measurements were examined in the IAD group. Compared to controls, IAD subjects exhibited reduced connectivity between the inferior ventral striatum and bilateral caudate head, subgenual anterior cingulate cortex (ACC), and posterior cingulate cortex, and between the superior ventral striatum and bilateral dorsal/rostral ACC, ventral anterior thalamus, and putamen/pallidum/insula/inferior frontal gyrus (IFG), and between the dorsal caudate and dorsal/rostral ACC, thalamus, and IFG, and between the left ventral rostral putamen and right IFG. IAD subjects also showed increased connectivity between the left dorsal caudal putamen and bilateral caudal cigulate motor area. Moreover, altered cotricostriatal functional circuits were significantly correlated with neuropsychological measures. This study directly provides evidence that IAD is associated with alterations of corticostriatal functional circuits involved in the affective and motivation processing, and cognitive control. These findings emphasize that functional connections in the corticostriatal circuits are modulated by affective/motivational/cognitive states and further suggest that IAD may have abnormalities of such modulation in this network. Frontiers Media S.A. 2015-06-16 /pmc/articles/PMC4468611/ /pubmed/26136677 http://dx.doi.org/10.3389/fnhum.2015.00356 Text en Copyright © 2015 Lin, Zhou, Du, Zhao, Qin, Xu and Lei. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lin, Fuchun
Zhou, Yan
Du, Yasong
Zhao, Zhimin
Qin, Lindi
Xu, Jianrong
Lei, Hao
Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder
title Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder
title_full Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder
title_fullStr Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder
title_full_unstemmed Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder
title_short Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder
title_sort aberrant corticostriatal functional circuits in adolescents with internet addiction disorder
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468611/
https://www.ncbi.nlm.nih.gov/pubmed/26136677
http://dx.doi.org/10.3389/fnhum.2015.00356
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