Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice

L-Kynurenine (L-KYN) is a central metabolite of tryptophan degradation through the kynurenine pathway (KP). The systemic administration of L-KYN sulfate (L-KYNs) leads to a rapid elevation of the neuroactive KP metabolite kynurenic acid (KYNA). An elevated level of KYNA may have multiple effects on...

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Detalles Bibliográficos
Autores principales: Varga, Dániel, Herédi, Judit, Kánvási, Zita, Ruszka, Marian, Kis, Zsolt, Ono, Etsuro, Iwamori, Naoki, Iwamori, Tokuko, Takakuwa, Hiroki, Vécsei, László, Toldi, József, Gellért, Levente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468612/
https://www.ncbi.nlm.nih.gov/pubmed/26136670
http://dx.doi.org/10.3389/fnbeh.2015.00157

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