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The role of exosomes in peripheral nerve regeneration
Peripheral nerve injuries remain problematic to treat, with poor functional recovery commonly observed. Injuries resulting in a nerve gap create specific difficulties for axonal regeneration. Approaches to address these difficulties include autologous nerve grafts (which are currently the gold stand...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468764/ https://www.ncbi.nlm.nih.gov/pubmed/26109947 http://dx.doi.org/10.4103/1673-5374.156968 |
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author | Ching, Rosanna C. Kingham, Paul J. |
author_facet | Ching, Rosanna C. Kingham, Paul J. |
author_sort | Ching, Rosanna C. |
collection | PubMed |
description | Peripheral nerve injuries remain problematic to treat, with poor functional recovery commonly observed. Injuries resulting in a nerve gap create specific difficulties for axonal regeneration. Approaches to address these difficulties include autologous nerve grafts (which are currently the gold standard treatment) and synthetic conduits, with the latter option being able to be impregnated with Schwann cells or stem cells which provide an appropriate micro-environment for neuronal regeneration to occur. Transplanting stem cells, however, infers additional risk of malignant transformation as well as manufacturing difficulties and ethical concerns, and the use of autologous nerve grafts and Schwann cells requires the sacrifice of a functioning nerve. A new approach utilizing exosomes, secreted extracellular vesicles, could avoid these complications. In this review, we summarize the current literature on exosomes, and suggest how they could help to improve axonal regeneration following peripheral nerve injury. |
format | Online Article Text |
id | pubmed-4468764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44687642015-06-24 The role of exosomes in peripheral nerve regeneration Ching, Rosanna C. Kingham, Paul J. Neural Regen Res Invited Review Peripheral nerve injuries remain problematic to treat, with poor functional recovery commonly observed. Injuries resulting in a nerve gap create specific difficulties for axonal regeneration. Approaches to address these difficulties include autologous nerve grafts (which are currently the gold standard treatment) and synthetic conduits, with the latter option being able to be impregnated with Schwann cells or stem cells which provide an appropriate micro-environment for neuronal regeneration to occur. Transplanting stem cells, however, infers additional risk of malignant transformation as well as manufacturing difficulties and ethical concerns, and the use of autologous nerve grafts and Schwann cells requires the sacrifice of a functioning nerve. A new approach utilizing exosomes, secreted extracellular vesicles, could avoid these complications. In this review, we summarize the current literature on exosomes, and suggest how they could help to improve axonal regeneration following peripheral nerve injury. Medknow Publications & Media Pvt Ltd 2015-05 /pmc/articles/PMC4468764/ /pubmed/26109947 http://dx.doi.org/10.4103/1673-5374.156968 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Review Ching, Rosanna C. Kingham, Paul J. The role of exosomes in peripheral nerve regeneration |
title | The role of exosomes in peripheral nerve regeneration |
title_full | The role of exosomes in peripheral nerve regeneration |
title_fullStr | The role of exosomes in peripheral nerve regeneration |
title_full_unstemmed | The role of exosomes in peripheral nerve regeneration |
title_short | The role of exosomes in peripheral nerve regeneration |
title_sort | role of exosomes in peripheral nerve regeneration |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468764/ https://www.ncbi.nlm.nih.gov/pubmed/26109947 http://dx.doi.org/10.4103/1673-5374.156968 |
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