Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death

The presence of lower molecular weight species comprising the C-terminal region of TAR DNA-binding protein 43 (TDP-43) is a characteristic of TDP-43 proteinopathy in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here, we have identified a novel splice variant of T...

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Detalles Bibliográficos
Autores principales: Xiao, Shangxi, Sanelli, Teresa, Chiang, Helen, Sun, Yulong, Chakrabartty, Avijit, Keith, Julia, Rogaeva, Ekaterina, Zinman, Lorne, Robertson, Janice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468798/
https://www.ncbi.nlm.nih.gov/pubmed/25788357
http://dx.doi.org/10.1007/s00401-015-1412-5

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