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Screening of COPD patients for abdominal aortic aneurysm
PURPOSE: Screening for abdominal aortic aneurysm (AAA) in “men aged over 65 years who have ever smoked” is a recommended policy. To reduce the number of screenings, it may be of value to define subgroups with a higher prevalence of AAA. Since chronic obstructive pulmonary disease (COPD) and AAA are...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468935/ https://www.ncbi.nlm.nih.gov/pubmed/26089658 http://dx.doi.org/10.2147/COPD.S81439 |
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author | Flessenkaemper, Ingo H Loddenkemper, Robert Roll, Stephanie Enke-Melzer, Kathrin Wurps, Henrik Bauer, Torsten T |
author_facet | Flessenkaemper, Ingo H Loddenkemper, Robert Roll, Stephanie Enke-Melzer, Kathrin Wurps, Henrik Bauer, Torsten T |
author_sort | Flessenkaemper, Ingo H |
collection | PubMed |
description | PURPOSE: Screening for abdominal aortic aneurysm (AAA) in “men aged over 65 years who have ever smoked” is a recommended policy. To reduce the number of screenings, it may be of value to define subgroups with a higher prevalence of AAA. Since chronic obstructive pulmonary disease (COPD) and AAA are associated with several common risk factors, this study investigates the prevalence of AAA in COPD patients. PATIENTS AND METHODS: Patients with COPD were identified via the hospital information system. Inclusion criteria were: COPD stage I–IV, ability to give full consent, and age >18 years; exclusion criteria were: patient too obese for an ultrasound check, previously diagnosed AAA, prior surgery for AAA, or ethical grounds such as concomitant advanced malignant or end-stage disease. The primary endpoint of the study was an aortic diameter measured by ultrasound of ≥30 mm. Defined secondary endpoints were evaluated on the basis of medical records and interviews. RESULTS: Of the 1,180 identified COPD patients, 589 were included in this prospective study. In 22 patients (3.70%), the aortic diameter was ≥30 mm, representing an AAA prevalence of 6.72% among males aged >65 years. The risk of AAA increased with the following comorbidities/risk factors: male sex (odds ratio [OR] 2.98), coronary heart disease (OR 2.81), peripheral arterial occlusive disease (OR 2.47), hyperlipoproteinemia (OR 2.77), AAA in the family history (OR 3.95), and COPD stage I/II versus IV (OR 1.81). CONCLUSION: The overall AAA prevalence of 3.7% in our group of COPD patients is similar to that of the general population aged >65 years. However, the frequency of AAA in male COPD patients aged >65 years is considerably higher (6.72%) and increased further still in those individuals with additional comorbidities/risk factors. Defining subgroups with a higher risk of AAA may increase the efficiency of screening. |
format | Online Article Text |
id | pubmed-4468935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44689352015-06-18 Screening of COPD patients for abdominal aortic aneurysm Flessenkaemper, Ingo H Loddenkemper, Robert Roll, Stephanie Enke-Melzer, Kathrin Wurps, Henrik Bauer, Torsten T Int J Chron Obstruct Pulmon Dis Original Research PURPOSE: Screening for abdominal aortic aneurysm (AAA) in “men aged over 65 years who have ever smoked” is a recommended policy. To reduce the number of screenings, it may be of value to define subgroups with a higher prevalence of AAA. Since chronic obstructive pulmonary disease (COPD) and AAA are associated with several common risk factors, this study investigates the prevalence of AAA in COPD patients. PATIENTS AND METHODS: Patients with COPD were identified via the hospital information system. Inclusion criteria were: COPD stage I–IV, ability to give full consent, and age >18 years; exclusion criteria were: patient too obese for an ultrasound check, previously diagnosed AAA, prior surgery for AAA, or ethical grounds such as concomitant advanced malignant or end-stage disease. The primary endpoint of the study was an aortic diameter measured by ultrasound of ≥30 mm. Defined secondary endpoints were evaluated on the basis of medical records and interviews. RESULTS: Of the 1,180 identified COPD patients, 589 were included in this prospective study. In 22 patients (3.70%), the aortic diameter was ≥30 mm, representing an AAA prevalence of 6.72% among males aged >65 years. The risk of AAA increased with the following comorbidities/risk factors: male sex (odds ratio [OR] 2.98), coronary heart disease (OR 2.81), peripheral arterial occlusive disease (OR 2.47), hyperlipoproteinemia (OR 2.77), AAA in the family history (OR 3.95), and COPD stage I/II versus IV (OR 1.81). CONCLUSION: The overall AAA prevalence of 3.7% in our group of COPD patients is similar to that of the general population aged >65 years. However, the frequency of AAA in male COPD patients aged >65 years is considerably higher (6.72%) and increased further still in those individuals with additional comorbidities/risk factors. Defining subgroups with a higher risk of AAA may increase the efficiency of screening. Dove Medical Press 2015-06-10 /pmc/articles/PMC4468935/ /pubmed/26089658 http://dx.doi.org/10.2147/COPD.S81439 Text en © 2015 Flessenkaemper et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Flessenkaemper, Ingo H Loddenkemper, Robert Roll, Stephanie Enke-Melzer, Kathrin Wurps, Henrik Bauer, Torsten T Screening of COPD patients for abdominal aortic aneurysm |
title | Screening of COPD patients for abdominal aortic aneurysm |
title_full | Screening of COPD patients for abdominal aortic aneurysm |
title_fullStr | Screening of COPD patients for abdominal aortic aneurysm |
title_full_unstemmed | Screening of COPD patients for abdominal aortic aneurysm |
title_short | Screening of COPD patients for abdominal aortic aneurysm |
title_sort | screening of copd patients for abdominal aortic aneurysm |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468935/ https://www.ncbi.nlm.nih.gov/pubmed/26089658 http://dx.doi.org/10.2147/COPD.S81439 |
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