Potential role of lampalizumab for treatment of geographic atrophy

The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive resul...

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Detalles Bibliográficos
Autores principales: Rhoades, William, Dickson, Drew, Do, Diana V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468985/
https://www.ncbi.nlm.nih.gov/pubmed/26089637
http://dx.doi.org/10.2147/OPTH.S59725
Descripción
Sumario:The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive results for the treatment of geographic atrophy in age-related macular degeneration. It has potential as a future treatment, and is currently undergoing a Phase III trial.

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