Potential role of lampalizumab for treatment of geographic atrophy

The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive resul...

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Detalles Bibliográficos
Autores principales: Rhoades, William, Dickson, Drew, Do, Diana V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468985/
https://www.ncbi.nlm.nih.gov/pubmed/26089637
http://dx.doi.org/10.2147/OPTH.S59725
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author Rhoades, William
Dickson, Drew
Do, Diana V
author_facet Rhoades, William
Dickson, Drew
Do, Diana V
author_sort Rhoades, William
collection PubMed
description The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive results for the treatment of geographic atrophy in age-related macular degeneration. It has potential as a future treatment, and is currently undergoing a Phase III trial.
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spelling pubmed-44689852015-06-18 Potential role of lampalizumab for treatment of geographic atrophy Rhoades, William Dickson, Drew Do, Diana V Clin Ophthalmol Review The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive results for the treatment of geographic atrophy in age-related macular degeneration. It has potential as a future treatment, and is currently undergoing a Phase III trial. Dove Medical Press 2015-06-11 /pmc/articles/PMC4468985/ /pubmed/26089637 http://dx.doi.org/10.2147/OPTH.S59725 Text en © 2015 Rhoades et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Rhoades, William
Dickson, Drew
Do, Diana V
Potential role of lampalizumab for treatment of geographic atrophy
title Potential role of lampalizumab for treatment of geographic atrophy
title_full Potential role of lampalizumab for treatment of geographic atrophy
title_fullStr Potential role of lampalizumab for treatment of geographic atrophy
title_full_unstemmed Potential role of lampalizumab for treatment of geographic atrophy
title_short Potential role of lampalizumab for treatment of geographic atrophy
title_sort potential role of lampalizumab for treatment of geographic atrophy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468985/
https://www.ncbi.nlm.nih.gov/pubmed/26089637
http://dx.doi.org/10.2147/OPTH.S59725
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