Non-Coding RNAs in Primary Liver Cancer

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with poor prognosis and limited therapeutic options. Over the past few years, many studies have evaluated the role of non-coding RNAs (ncRNAs) in hepatocarcinogenesis and tumor progression. ncRNAs were shown to have diagnostic, prog...

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Detalles Bibliográficos
Autores principales: Ghidini, Michele, Braconi, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469108/
https://www.ncbi.nlm.nih.gov/pubmed/26131450
http://dx.doi.org/10.3389/fmed.2015.00036
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author Ghidini, Michele
Braconi, Chiara
author_facet Ghidini, Michele
Braconi, Chiara
author_sort Ghidini, Michele
collection PubMed
description Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with poor prognosis and limited therapeutic options. Over the past few years, many studies have evaluated the role of non-coding RNAs (ncRNAs) in hepatocarcinogenesis and tumor progression. ncRNAs were shown to have diagnostic, prognostic, and therapeutic potential in HCC. In this manuscript, we review the latest major discoveries concerning microRNAs and long ncRNAs in HCC pathogenesis, and discuss the potentials and the limitations for their use in clinical practice.
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spelling pubmed-44691082015-06-30 Non-Coding RNAs in Primary Liver Cancer Ghidini, Michele Braconi, Chiara Front Med (Lausanne) Medicine Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with poor prognosis and limited therapeutic options. Over the past few years, many studies have evaluated the role of non-coding RNAs (ncRNAs) in hepatocarcinogenesis and tumor progression. ncRNAs were shown to have diagnostic, prognostic, and therapeutic potential in HCC. In this manuscript, we review the latest major discoveries concerning microRNAs and long ncRNAs in HCC pathogenesis, and discuss the potentials and the limitations for their use in clinical practice. Frontiers Media S.A. 2015-06-04 /pmc/articles/PMC4469108/ /pubmed/26131450 http://dx.doi.org/10.3389/fmed.2015.00036 Text en Copyright © 2015 Ghidini and Braconi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Ghidini, Michele
Braconi, Chiara
Non-Coding RNAs in Primary Liver Cancer
title Non-Coding RNAs in Primary Liver Cancer
title_full Non-Coding RNAs in Primary Liver Cancer
title_fullStr Non-Coding RNAs in Primary Liver Cancer
title_full_unstemmed Non-Coding RNAs in Primary Liver Cancer
title_short Non-Coding RNAs in Primary Liver Cancer
title_sort non-coding rnas in primary liver cancer
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469108/
https://www.ncbi.nlm.nih.gov/pubmed/26131450
http://dx.doi.org/10.3389/fmed.2015.00036
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