Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas

Overexpression of the high-mobility group A (HMGA)1 and HMGA2 proteins is a feature of all human pituitary adenoma (PAs) subtypes. However, amplification and/or rearrangement of the HMGA2 have been described in human prolactinomas, but rarely in other pituitary subtypes, and no genomic amplification...

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Autores principales: D’Angelo, Daniela, Esposito, Francesco, Fusco, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469109/
https://www.ncbi.nlm.nih.gov/pubmed/26137461
http://dx.doi.org/10.3389/fmed.2015.00039
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author D’Angelo, Daniela
Esposito, Francesco
Fusco, Alfredo
author_facet D’Angelo, Daniela
Esposito, Francesco
Fusco, Alfredo
author_sort D’Angelo, Daniela
collection PubMed
description Overexpression of the high-mobility group A (HMGA)1 and HMGA2 proteins is a feature of all human pituitary adenoma (PAs) subtypes. However, amplification and/or rearrangement of the HMGA2 have been described in human prolactinomas, but rarely in other pituitary subtypes, and no genomic amplification of HMGA1 was detected in PAs. Here, we summarize the functional role of HMGA proteins in pituitary tumorigenesis and the epigenetic mechanisms contributing to HMGA overexpression in these tumors focusing on recent studies indicating a critical role of non-coding RNAs in modulating HMGA protein levels.
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spelling pubmed-44691092015-07-01 Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas D’Angelo, Daniela Esposito, Francesco Fusco, Alfredo Front Med (Lausanne) Medicine Overexpression of the high-mobility group A (HMGA)1 and HMGA2 proteins is a feature of all human pituitary adenoma (PAs) subtypes. However, amplification and/or rearrangement of the HMGA2 have been described in human prolactinomas, but rarely in other pituitary subtypes, and no genomic amplification of HMGA1 was detected in PAs. Here, we summarize the functional role of HMGA proteins in pituitary tumorigenesis and the epigenetic mechanisms contributing to HMGA overexpression in these tumors focusing on recent studies indicating a critical role of non-coding RNAs in modulating HMGA protein levels. Frontiers Media S.A. 2015-06-08 /pmc/articles/PMC4469109/ /pubmed/26137461 http://dx.doi.org/10.3389/fmed.2015.00039 Text en Copyright © 2015 D’Angelo, Esposito and Fusco. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
D’Angelo, Daniela
Esposito, Francesco
Fusco, Alfredo
Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas
title Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas
title_full Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas
title_fullStr Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas
title_full_unstemmed Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas
title_short Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas
title_sort epigenetic mechanisms leading to overexpression of hmga proteins in human pituitary adenomas
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469109/
https://www.ncbi.nlm.nih.gov/pubmed/26137461
http://dx.doi.org/10.3389/fmed.2015.00039
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