Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application

Dynamic preservation strategies such as hypothermic machine perfusion are increasingly discussed to improve liver graft quality before transplantation. This review summarizes current knowledge of this perfusion technique for liver preservation. We discuss optimization of perfusion conditions and cur...

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Detalles Bibliográficos
Autores principales: Schlegel, A., Kron, P., Dutkowski, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Machine Preservation of the Liver (CM Miller, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469295/
https://www.ncbi.nlm.nih.gov/pubmed/26097802
http://dx.doi.org/10.1007/s40472-014-0046-1
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author Schlegel, A.
Kron, P.
Dutkowski, P.
author_facet Schlegel, A.
Kron, P.
Dutkowski, P.
author_sort Schlegel, A.
collection PubMed
description Dynamic preservation strategies such as hypothermic machine perfusion are increasingly discussed to improve liver graft quality before transplantation. This review summarizes current knowledge of this perfusion technique for liver preservation. We discuss optimization of perfusion conditions and current strategies to assess graft quality during cold perfusion. Next, we provide an overview of possible pathways of protection from ischemia-reperfusion injury. Finally, we report on recent clinical applications of human hypothermic machine liver perfusion.
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spelling pubmed-44692952015-06-17 Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application Schlegel, A. Kron, P. Dutkowski, P. Curr Transplant Rep Machine Preservation of the Liver (CM Miller, Section Editor) Dynamic preservation strategies such as hypothermic machine perfusion are increasingly discussed to improve liver graft quality before transplantation. This review summarizes current knowledge of this perfusion technique for liver preservation. We discuss optimization of perfusion conditions and current strategies to assess graft quality during cold perfusion. Next, we provide an overview of possible pathways of protection from ischemia-reperfusion injury. Finally, we report on recent clinical applications of human hypothermic machine liver perfusion. Springer International Publishing 2015-02-10 2015 /pmc/articles/PMC4469295/ /pubmed/26097802 http://dx.doi.org/10.1007/s40472-014-0046-1 Text en © Springer International Publishing AG 2015
spellingShingle Machine Preservation of the Liver (CM Miller, Section Editor)
Schlegel, A.
Kron, P.
Dutkowski, P.
Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application
title Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application
title_full Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application
title_fullStr Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application
title_full_unstemmed Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application
title_short Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application
title_sort hypothermic oxygenated liver perfusion: basic mechanisms and clinical application
topic Machine Preservation of the Liver (CM Miller, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469295/
https://www.ncbi.nlm.nih.gov/pubmed/26097802
http://dx.doi.org/10.1007/s40472-014-0046-1
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