Circadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients

The anti-estrogen tamoxifen is characterized by a large variability in response, partly due to pharmacokinetic differences. We examined circadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients. Pharmacokinetic analysis was performed in mice, dosed at six different times (...

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Detalles Bibliográficos
Autores principales: Binkhorst, Lisette, Kloth, Jacqueline S. L., de Wit, Annelieke S., de Bruijn, Peter, Lam, Mei H., Chaves, Ines, Burger, Herman, van Alphen, Robbert J., Hamberg, Paul, van Schaik, Ron H. N., Jager, Agnes, Koch, Birgit C. P., Wiemer, Erik A. C., van Gelder, Teun, van der Horst, Gijsbertus T. J., Mathijssen, Ron H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Clinical Trial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469299/
https://www.ncbi.nlm.nih.gov/pubmed/26050156
http://dx.doi.org/10.1007/s10549-015-3452-x

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