Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein

MET has gained interest as a therapeutic target for a number of malignancies because of its involvement in tumorigenesis, invasion and metastasis. At present, a number of inhibitors, both antibodies against MET or its ligand hepatocyte growth factor, and small molecule MET tyrosine kinase inhibitors...

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Detalles Bibliográficos
Autores principales: Navis, Anna C., van Lith, Sanne A. M., van Duijnhoven, Sander M. J., de Pooter, Maaike, Yetkin-Arik, Bahar, Wesseling, Pieter, Hendriks, Wiljan J. A. J., Venselaar, Hanka, Timmer, Marco, van Cleef, Patricia, van Bergen en Henegouwen, Paul, Best, Myron G., Wurdinger, Thomas D., Tops, Bastiaan B. J., Leenders, William P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469304/
https://www.ncbi.nlm.nih.gov/pubmed/25862637
http://dx.doi.org/10.1007/s00401-015-1420-5

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