Cargando…
Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?
Hepatitis B virus (HBV) replication and persistence are sustained by a nuclear episome, the covalently closed circular (CCC) DNA, which serves as the transcriptional template for all viral RNAs. CCC DNA is converted from a relaxed circular (RC) DNA in the virion early during infection as well as fro...
Autores principales: | Cui, Xiuji, McAllister, Rebecca, Boregowda, Rajeev, Sohn, Ji A., Ledesma, Felipe Cortes, Caldecott, Keith W., Seeger, Christoph, Hu, Jianming |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469307/ https://www.ncbi.nlm.nih.gov/pubmed/26079492 http://dx.doi.org/10.1371/journal.pone.0128401 |
Ejemplares similares
-
TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage
por: Zeng, Zhihong, et al.
Publicado: (2011) -
Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair
por: Huang, Shar-yin Naomi, et al.
Publicado: (2019) -
Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites
por: Lebedeva, Natalia A., et al.
Publicado: (2012) -
New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2
por: Salomatina, Oksana V., et al.
Publicado: (2021) -
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2
por: Hornyak, Peter, et al.
Publicado: (2016)