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Modeling of the OX(1)R–orexin-A complex suggests two alternative binding modes

BACKGROUND: Interactions between the orexin peptides and their cognate OX(1) and OX(2) receptors remain poorly characterized. Site-directed mutagenesis studies on orexin peptides and receptors have indicated amino acids important for ligand binding and receptor activation. However, a better understa...

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Detalles Bibliográficos
Autores principales:	Karhu, Lasse, Turku, Ainoleena, Xhaard, Henri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469407/ https://www.ncbi.nlm.nih.gov/pubmed/25957175 http://dx.doi.org/10.1186/s12900-015-0036-2

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