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Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways

Background: Mendelian randomization uses genetic variants, assumed to be instrumental variables for a particular exposure, to estimate the causal effect of that exposure on an outcome. If the instrumental variable criteria are satisfied, the resulting estimator is consistent even in the presence of...

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Detalles Bibliográficos
Autores principales:	Burgess, Stephen, Daniel, Rhian M, Butterworth, Adam S, Thompson, Simon G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Mendelian Randomization Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469795/ https://www.ncbi.nlm.nih.gov/pubmed/25150977 http://dx.doi.org/10.1093/ije/dyu176

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