Cargando…

Lipoic acid decreases Mcl-1, Bcl-x(L) and up regulates Bim on ovarian carcinoma cells leading to cell death

BACKGROUND: Ovarian carcinoma is the leading cause of death from gynecological cancer because there is risk of chemoresistance. As previously demonstrated in our laboratory, Alpha-lipoic acid (LA), a co-factor for metabolic enzymes, suppresses the tumor growth. In this study, we have researched the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kafara, Perrine, Icard, Philippe, Guillamin, Marilyne, Schwartz, Laurent, Lincet, Hubert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470044/ https://www.ncbi.nlm.nih.gov/pubmed/26063499 http://dx.doi.org/10.1186/s13048-015-0165-z

Ejemplares similares

Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-x(L) inhibitors on human ovarian carcinoma cells
por: Lincet, Hubert, et al.
Publicado: (2013)

Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation
por: Farhat, Diana, et al.
Publicado: (2020)

Trichonomas vaginalis Metalloproteinase Induces Apoptosis of SiHa Cells through Disrupting the Mcl-1/Bim and Bcl-xL/Bim Complexes
por: Quan, Juan-Hua, et al.
Publicado: (2014)

Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-x(L) Binding to Bim
por: Cheng, Chunwei, et al.
Publicado: (2014)

Roscovitine-induced Apoptosis in Neutrophils and Neutrophil Progenitors Is Regulated by the Bcl-2-Family Members Bim, Puma, Noxa and Mcl-1
por: Gautam, Sanjivan, et al.
Publicado: (2013)

Correction: Roscovitine-induced Apoptosis in Neutrophils and Neutrophil Progenitors Is Regulated by the Bcl-2-Family Members Bim, Puma, Noxa and Mcl-1
por: Gautam, Sanjivan, et al.
Publicado: (2014)

BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells
por: Sharma, A, et al.
Publicado: (2013)

Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
por: Icard, Philippe, et al.
Publicado: (2021)

Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/BAK hetero-complexes
por: Seiller, Carolane, et al.
Publicado: (2020)

Citrate targets FBPase and constitutes an emerging novel approach for cancer therapy
por: Icard, Philippe, et al.
Publicado: (2018)

The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest
por: Haschka, Manuel D., et al.
Publicado: (2015)

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival
por: Lee, Erinna F., et al.
Publicado: (2019)

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis
por: Wojciechowski, Sara, et al.
Publicado: (2007)

Cafestol overcomes ABT-737 resistance in Mcl-1-overexpressed renal carcinoma Caki cells through downregulation of Mcl-1 expression and upregulation of Bim expression
por: Woo, S M, et al.
Publicado: (2014)

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration
por: Hagenbuchner, Judith, et al.
Publicado: (2013)

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide
por: Hadji, Abbas, et al.
Publicado: (2019)

Bim and Mcl-1 exert key roles in regulating JAK2(V617F )cell survival
por: Rubert, Joëlle, et al.
Publicado: (2011)

Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-x(L) strategies through Mcl-1 down-regulation
por: Bonnefond, Marie-Laure, et al.
Publicado: (2015)

The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response
por: Icard, Philippe, et al.
Publicado: (2021)

miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-X(L) and EGFR leading to BIM activation
por: Denoyelle, C, et al.
Publicado: (2014)

Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 axis
por: Wang, X, et al.
Publicado: (2012)

Marinopyrrole Derivatives with Sulfide Spacers as Selective Disruptors of Mcl-1 Binding to Pro-Apoptotic Protein Bim
por: Cheng, Chunwei, et al.
Publicado: (2014)

BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors
por: Korfi, K, et al.
Publicado: (2016)

Inhibition of Antiapoptotic BCL-XL, BCL-2, and MCL-1 Proteins by Small Molecule Mimetics
por: Dalafave, D.S., et al.
Publicado: (2010)

Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis
por: Zhang, Jingyi, et al.
Publicado: (2022)

Mcl‐1 and Bcl‐xL levels predict responsiveness to dual MEK/Bcl‐2 inhibition in B‐cell malignancies
por: Melvold, Katrine, et al.
Publicado: (2021)

Sensitization of ovarian carcinoma cells to Bcl-x(L)-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family
por: Tomasina, Julie, et al.
Publicado: (2013)

Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim
por: Nguyen, Mai, et al.
Publicado: (2015)

Simultaneous Inhibition of Mcl-1 and Bcl-2 Induces Synergistic Cell Death in Hepatocellular Carcinoma
por: Michalski, Marlen, et al.
Publicado: (2023)

MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-X(L) expression
por: Yasuda, Yuto, et al.
Publicado: (2020)

Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-1-regulated apoptosis in pancreatic cancer cells
por: Burmi, Rajpal S., et al.
Publicado: (2018)

Co-inhibition of BCL-XL and MCL-1 with selective BCL-2 family inhibitors enhances cytotoxicity of cervical cancer cell lines
por: Abdul Rahman, Siti Fairus, et al.
Publicado: (2020)

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL
por: Vikström, Ingela B, et al.
Publicado: (2016)

Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis
por: Singh, Prafull Kumar, et al.
Publicado: (2017)

Sensitivity of Cutaneous T-Cell Lymphoma Cells to the Mcl-1 Inhibitor S63845 Correlates with the Lack of Bcl-w Expression
por: Sumarni, Uly, et al.
Publicado: (2022)

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice
por: Herold, M J, et al.
Publicado: (2014)

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
por: Rautureau, G J P, et al.
Publicado: (2012)

Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1
por: Ow, Thomas J., et al.
Publicado: (2019)

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance
por: Colli, Maikel L., et al.
Publicado: (2011)

c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1
por: Campone, Mario, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ao6g3h3v3ugb41gkdcnvu881o6