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Extrinsic and intrinsic regulation of axon regeneration at a crossroads
Repair of the injured spinal cord is a major challenge in medicine. The limited intrinsic regenerative response mounted by adult central nervous system (CNS) neurons is further hampered by astrogliosis, myelin debris and scar tissue that characterize the damaged CNS. Improved axon regeneration and r...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470051/ https://www.ncbi.nlm.nih.gov/pubmed/26136657 http://dx.doi.org/10.3389/fnmol.2015.00027 |
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author | Kaplan, Andrew Ong Tone, Stephan Fournier, Alyson E. |
author_facet | Kaplan, Andrew Ong Tone, Stephan Fournier, Alyson E. |
author_sort | Kaplan, Andrew |
collection | PubMed |
description | Repair of the injured spinal cord is a major challenge in medicine. The limited intrinsic regenerative response mounted by adult central nervous system (CNS) neurons is further hampered by astrogliosis, myelin debris and scar tissue that characterize the damaged CNS. Improved axon regeneration and recovery can be elicited by targeting extrinsic factors as well as by boosting neuron-intrinsic growth regulators. Our knowledge of the molecular basis of intrinsic and extrinsic regulators of regeneration has expanded rapidly, resulting in promising new targets to promote repair. Intriguingly certain neuron-intrinsic growth regulators are emerging as promising targets to both stimulate growth and relieve extrinsic inhibition of regeneration. This crossroads between the intrinsic and extrinsic aspects of spinal cord injury is a promising target for effective therapies for this unmet need. |
format | Online Article Text |
id | pubmed-4470051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44700512015-07-01 Extrinsic and intrinsic regulation of axon regeneration at a crossroads Kaplan, Andrew Ong Tone, Stephan Fournier, Alyson E. Front Mol Neurosci Neuroscience Repair of the injured spinal cord is a major challenge in medicine. The limited intrinsic regenerative response mounted by adult central nervous system (CNS) neurons is further hampered by astrogliosis, myelin debris and scar tissue that characterize the damaged CNS. Improved axon regeneration and recovery can be elicited by targeting extrinsic factors as well as by boosting neuron-intrinsic growth regulators. Our knowledge of the molecular basis of intrinsic and extrinsic regulators of regeneration has expanded rapidly, resulting in promising new targets to promote repair. Intriguingly certain neuron-intrinsic growth regulators are emerging as promising targets to both stimulate growth and relieve extrinsic inhibition of regeneration. This crossroads between the intrinsic and extrinsic aspects of spinal cord injury is a promising target for effective therapies for this unmet need. Frontiers Media S.A. 2015-06-16 /pmc/articles/PMC4470051/ /pubmed/26136657 http://dx.doi.org/10.3389/fnmol.2015.00027 Text en Copyright © 2015 Kaplan, Ong Tone and Fournier. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Kaplan, Andrew Ong Tone, Stephan Fournier, Alyson E. Extrinsic and intrinsic regulation of axon regeneration at a crossroads |
title | Extrinsic and intrinsic regulation of axon regeneration at a crossroads |
title_full | Extrinsic and intrinsic regulation of axon regeneration at a crossroads |
title_fullStr | Extrinsic and intrinsic regulation of axon regeneration at a crossroads |
title_full_unstemmed | Extrinsic and intrinsic regulation of axon regeneration at a crossroads |
title_short | Extrinsic and intrinsic regulation of axon regeneration at a crossroads |
title_sort | extrinsic and intrinsic regulation of axon regeneration at a crossroads |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470051/ https://www.ncbi.nlm.nih.gov/pubmed/26136657 http://dx.doi.org/10.3389/fnmol.2015.00027 |
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