Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?

The antitumor effect of bisphosphonates (BPs) is under increasing scrutiny. Preclinical and clinical evidence has shown that BPs might sensitize breast tumors to chemotherapy. Here, we present a review of current preclinical and clinical evidence for antitumor effects of BPs, and evaluate how BPs mi...

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Detalles Bibliográficos
Autores principales: Charehbili, Ayoub, Fontein, Duveken B. Y., Kroep, Judith R., Liefers, Gerrit-Jan, Nortier, Johannes W. R., van de Velde, Cornelis J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470143/
https://www.ncbi.nlm.nih.gov/pubmed/26237143
http://dx.doi.org/10.3390/jcm2040188
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author Charehbili, Ayoub
Fontein, Duveken B. Y.
Kroep, Judith R.
Liefers, Gerrit-Jan
Nortier, Johannes W. R.
van de Velde, Cornelis J. H.
author_facet Charehbili, Ayoub
Fontein, Duveken B. Y.
Kroep, Judith R.
Liefers, Gerrit-Jan
Nortier, Johannes W. R.
van de Velde, Cornelis J. H.
author_sort Charehbili, Ayoub
collection PubMed
description The antitumor effect of bisphosphonates (BPs) is under increasing scrutiny. Preclinical and clinical evidence has shown that BPs might sensitize breast tumors to chemotherapy. Here, we present a review of current preclinical and clinical evidence for antitumor effects of BPs, and evaluate how BPs might play a role in neoadjuvant treatment of women with breast cancer.
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spelling pubmed-44701432015-07-28 Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy? Charehbili, Ayoub Fontein, Duveken B. Y. Kroep, Judith R. Liefers, Gerrit-Jan Nortier, Johannes W. R. van de Velde, Cornelis J. H. J Clin Med Article The antitumor effect of bisphosphonates (BPs) is under increasing scrutiny. Preclinical and clinical evidence has shown that BPs might sensitize breast tumors to chemotherapy. Here, we present a review of current preclinical and clinical evidence for antitumor effects of BPs, and evaluate how BPs might play a role in neoadjuvant treatment of women with breast cancer. MDPI 2013-10-16 /pmc/articles/PMC4470143/ /pubmed/26237143 http://dx.doi.org/10.3390/jcm2040188 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Charehbili, Ayoub
Fontein, Duveken B. Y.
Kroep, Judith R.
Liefers, Gerrit-Jan
Nortier, Johannes W. R.
van de Velde, Cornelis J. H.
Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
title Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
title_full Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
title_fullStr Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
title_full_unstemmed Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
title_short Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
title_sort can zoledronic acid be beneficial for promoting tumor response in breast cancer patients treated with neoadjuvant chemotherapy?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470143/
https://www.ncbi.nlm.nih.gov/pubmed/26237143
http://dx.doi.org/10.3390/jcm2040188
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