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Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage

Hyponatremia is the most frequently encountered electrolyte abnormality in critically ill patients. Hyponatremia on admission has been identified as an independent predictor of in-hospital mortality in patients with spontaneous intracerebral hemorrhage (sICH). However, the incidence and etiology of...

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Autores principales: Robenolt Gray, Jaime, Morbitzer, Kathryn A., Liu-DeRyke, Xi, Parker, Dennis, Hall Zimmerman, Lisa, Rhoney, Denise H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470185/
https://www.ncbi.nlm.nih.gov/pubmed/26237605
http://dx.doi.org/10.3390/jcm3041322
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author Robenolt Gray, Jaime
Morbitzer, Kathryn A.
Liu-DeRyke, Xi
Parker, Dennis
Hall Zimmerman, Lisa
Rhoney, Denise H.
author_facet Robenolt Gray, Jaime
Morbitzer, Kathryn A.
Liu-DeRyke, Xi
Parker, Dennis
Hall Zimmerman, Lisa
Rhoney, Denise H.
author_sort Robenolt Gray, Jaime
collection PubMed
description Hyponatremia is the most frequently encountered electrolyte abnormality in critically ill patients. Hyponatremia on admission has been identified as an independent predictor of in-hospital mortality in patients with spontaneous intracerebral hemorrhage (sICH). However, the incidence and etiology of hyponatremia (HN) during hospitalization in a neurointensive care unit following spontaneous intracerebral hemorrhage (sICH) remains unknown. This was a retrospective analysis of consecutive patients admitted to Detroit Receiving Hospital for sICH between January 2006 and July 2009. All serum Na levels were recorded for patients during the ICU stay. HN was defined as Na <135 mmol/L. A total of 99 patients were analyzed with HN developing in 24% of sICH patients. Patients with HN had an average sodium nadir of 130 ± 3 mmol/L and an average time from admission to sodium <135 mmol/L of 3.9 ± 5.7 days. The most common cause of hyponatremia was syndrome of inappropriate antidiuretic hormone (90% of HN patients). Patients with HN were more likely to have fever (50% vs. 23%; p = 0.01), infection (58% vs. 28%; p = 0.007) as well as a longer hospital length of stay (14 (8–25) vs. 6 (3–9) days; p < 0.001). Of the patients who developed HN, fifteen (62.5%) patients developed HN in the first week following sICH. This shows HN has a fairly high incidence following sICH. The presence of HN is associated with longer hospital length of stays and higher rates of patient complications, which may result in worse patient outcomes. Further study is necessary to characterize the clinical relevance and treatment of HN in this population.
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spelling pubmed-44701852015-07-28 Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage Robenolt Gray, Jaime Morbitzer, Kathryn A. Liu-DeRyke, Xi Parker, Dennis Hall Zimmerman, Lisa Rhoney, Denise H. J Clin Med Article Hyponatremia is the most frequently encountered electrolyte abnormality in critically ill patients. Hyponatremia on admission has been identified as an independent predictor of in-hospital mortality in patients with spontaneous intracerebral hemorrhage (sICH). However, the incidence and etiology of hyponatremia (HN) during hospitalization in a neurointensive care unit following spontaneous intracerebral hemorrhage (sICH) remains unknown. This was a retrospective analysis of consecutive patients admitted to Detroit Receiving Hospital for sICH between January 2006 and July 2009. All serum Na levels were recorded for patients during the ICU stay. HN was defined as Na <135 mmol/L. A total of 99 patients were analyzed with HN developing in 24% of sICH patients. Patients with HN had an average sodium nadir of 130 ± 3 mmol/L and an average time from admission to sodium <135 mmol/L of 3.9 ± 5.7 days. The most common cause of hyponatremia was syndrome of inappropriate antidiuretic hormone (90% of HN patients). Patients with HN were more likely to have fever (50% vs. 23%; p = 0.01), infection (58% vs. 28%; p = 0.007) as well as a longer hospital length of stay (14 (8–25) vs. 6 (3–9) days; p < 0.001). Of the patients who developed HN, fifteen (62.5%) patients developed HN in the first week following sICH. This shows HN has a fairly high incidence following sICH. The presence of HN is associated with longer hospital length of stays and higher rates of patient complications, which may result in worse patient outcomes. Further study is necessary to characterize the clinical relevance and treatment of HN in this population. MDPI 2014-11-20 /pmc/articles/PMC4470185/ /pubmed/26237605 http://dx.doi.org/10.3390/jcm3041322 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Robenolt Gray, Jaime
Morbitzer, Kathryn A.
Liu-DeRyke, Xi
Parker, Dennis
Hall Zimmerman, Lisa
Rhoney, Denise H.
Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage
title Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage
title_full Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage
title_fullStr Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage
title_full_unstemmed Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage
title_short Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage
title_sort hyponatremia in patients with spontaneous intracerebral hemorrhage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470185/
https://www.ncbi.nlm.nih.gov/pubmed/26237605
http://dx.doi.org/10.3390/jcm3041322
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