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Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage
Hyponatremia is the most frequently encountered electrolyte abnormality in critically ill patients. Hyponatremia on admission has been identified as an independent predictor of in-hospital mortality in patients with spontaneous intracerebral hemorrhage (sICH). However, the incidence and etiology of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470185/ https://www.ncbi.nlm.nih.gov/pubmed/26237605 http://dx.doi.org/10.3390/jcm3041322 |
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author | Robenolt Gray, Jaime Morbitzer, Kathryn A. Liu-DeRyke, Xi Parker, Dennis Hall Zimmerman, Lisa Rhoney, Denise H. |
author_facet | Robenolt Gray, Jaime Morbitzer, Kathryn A. Liu-DeRyke, Xi Parker, Dennis Hall Zimmerman, Lisa Rhoney, Denise H. |
author_sort | Robenolt Gray, Jaime |
collection | PubMed |
description | Hyponatremia is the most frequently encountered electrolyte abnormality in critically ill patients. Hyponatremia on admission has been identified as an independent predictor of in-hospital mortality in patients with spontaneous intracerebral hemorrhage (sICH). However, the incidence and etiology of hyponatremia (HN) during hospitalization in a neurointensive care unit following spontaneous intracerebral hemorrhage (sICH) remains unknown. This was a retrospective analysis of consecutive patients admitted to Detroit Receiving Hospital for sICH between January 2006 and July 2009. All serum Na levels were recorded for patients during the ICU stay. HN was defined as Na <135 mmol/L. A total of 99 patients were analyzed with HN developing in 24% of sICH patients. Patients with HN had an average sodium nadir of 130 ± 3 mmol/L and an average time from admission to sodium <135 mmol/L of 3.9 ± 5.7 days. The most common cause of hyponatremia was syndrome of inappropriate antidiuretic hormone (90% of HN patients). Patients with HN were more likely to have fever (50% vs. 23%; p = 0.01), infection (58% vs. 28%; p = 0.007) as well as a longer hospital length of stay (14 (8–25) vs. 6 (3–9) days; p < 0.001). Of the patients who developed HN, fifteen (62.5%) patients developed HN in the first week following sICH. This shows HN has a fairly high incidence following sICH. The presence of HN is associated with longer hospital length of stays and higher rates of patient complications, which may result in worse patient outcomes. Further study is necessary to characterize the clinical relevance and treatment of HN in this population. |
format | Online Article Text |
id | pubmed-4470185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44701852015-07-28 Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage Robenolt Gray, Jaime Morbitzer, Kathryn A. Liu-DeRyke, Xi Parker, Dennis Hall Zimmerman, Lisa Rhoney, Denise H. J Clin Med Article Hyponatremia is the most frequently encountered electrolyte abnormality in critically ill patients. Hyponatremia on admission has been identified as an independent predictor of in-hospital mortality in patients with spontaneous intracerebral hemorrhage (sICH). However, the incidence and etiology of hyponatremia (HN) during hospitalization in a neurointensive care unit following spontaneous intracerebral hemorrhage (sICH) remains unknown. This was a retrospective analysis of consecutive patients admitted to Detroit Receiving Hospital for sICH between January 2006 and July 2009. All serum Na levels were recorded for patients during the ICU stay. HN was defined as Na <135 mmol/L. A total of 99 patients were analyzed with HN developing in 24% of sICH patients. Patients with HN had an average sodium nadir of 130 ± 3 mmol/L and an average time from admission to sodium <135 mmol/L of 3.9 ± 5.7 days. The most common cause of hyponatremia was syndrome of inappropriate antidiuretic hormone (90% of HN patients). Patients with HN were more likely to have fever (50% vs. 23%; p = 0.01), infection (58% vs. 28%; p = 0.007) as well as a longer hospital length of stay (14 (8–25) vs. 6 (3–9) days; p < 0.001). Of the patients who developed HN, fifteen (62.5%) patients developed HN in the first week following sICH. This shows HN has a fairly high incidence following sICH. The presence of HN is associated with longer hospital length of stays and higher rates of patient complications, which may result in worse patient outcomes. Further study is necessary to characterize the clinical relevance and treatment of HN in this population. MDPI 2014-11-20 /pmc/articles/PMC4470185/ /pubmed/26237605 http://dx.doi.org/10.3390/jcm3041322 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Robenolt Gray, Jaime Morbitzer, Kathryn A. Liu-DeRyke, Xi Parker, Dennis Hall Zimmerman, Lisa Rhoney, Denise H. Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage |
title | Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage |
title_full | Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage |
title_fullStr | Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage |
title_full_unstemmed | Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage |
title_short | Hyponatremia in Patients with Spontaneous Intracerebral Hemorrhage |
title_sort | hyponatremia in patients with spontaneous intracerebral hemorrhage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470185/ https://www.ncbi.nlm.nih.gov/pubmed/26237605 http://dx.doi.org/10.3390/jcm3041322 |
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