Targeted Therapy of FLT3 in Treatment of AML—Current Status and Future Directions

Internal tandem duplications (ITDs) of the gene encoding the Fms-Like Tyrosine kinase-3 (FLT3) receptor are present in approximately 25% of patients with acute myeloid leukemia (AML). The mutation is associated with poor prognosis, and the aberrant protein product has been hypothesized as an attract...

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Detalles Bibliográficos
Autores principales: Engen, Caroline Benedicte Nitter, Wergeland, Line, Skavland, Jørn, Gjertsen, Bjørn Tore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470194/
https://www.ncbi.nlm.nih.gov/pubmed/26237612
http://dx.doi.org/10.3390/jcm3041466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470194/
https://www.ncbi.nlm.nih.gov/pubmed/26237612
http://dx.doi.org/10.3390/jcm3041466

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