The State of Play with iPSCs and Spinal Cord Injury Models

The application of induced pluripotent stem cell (iPSC) technologies in cell based strategies, for the repair of the central nervous system (with particular focus on the spinal cord), is moving towards the potential use of clinical grade donor cells. The ability of iPSCs to generate donor neuronal,...

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Detalles Bibliográficos
Autores principales: Hodgetts, Stuart I., Edel, Michael, Harvey, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470248/
https://www.ncbi.nlm.nih.gov/pubmed/26237027
http://dx.doi.org/10.3390/jcm4010193
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author Hodgetts, Stuart I.
Edel, Michael
Harvey, Alan R.
author_facet Hodgetts, Stuart I.
Edel, Michael
Harvey, Alan R.
author_sort Hodgetts, Stuart I.
collection PubMed
description The application of induced pluripotent stem cell (iPSC) technologies in cell based strategies, for the repair of the central nervous system (with particular focus on the spinal cord), is moving towards the potential use of clinical grade donor cells. The ability of iPSCs to generate donor neuronal, glial and astrocytic phenotypes for transplantation is highlighted here, and we review recent research using iPSCs in attempts to treat spinal cord injury in various animal models. Also discussed are issues relating to the production of clinical grade iPSCs, recent advances in transdifferentiation protocols for iPSC-derived donor cell populations, concerns about tumourogenicity, and whether iPSC technologies offer any advantages over previous donor cell candidates or tissues already in use as therapeutic tools in experimental spinal cord injury studies.
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spelling pubmed-44702482015-07-28 The State of Play with iPSCs and Spinal Cord Injury Models Hodgetts, Stuart I. Edel, Michael Harvey, Alan R. J Clin Med Commentary The application of induced pluripotent stem cell (iPSC) technologies in cell based strategies, for the repair of the central nervous system (with particular focus on the spinal cord), is moving towards the potential use of clinical grade donor cells. The ability of iPSCs to generate donor neuronal, glial and astrocytic phenotypes for transplantation is highlighted here, and we review recent research using iPSCs in attempts to treat spinal cord injury in various animal models. Also discussed are issues relating to the production of clinical grade iPSCs, recent advances in transdifferentiation protocols for iPSC-derived donor cell populations, concerns about tumourogenicity, and whether iPSC technologies offer any advantages over previous donor cell candidates or tissues already in use as therapeutic tools in experimental spinal cord injury studies. MDPI 2015-01-14 /pmc/articles/PMC4470248/ /pubmed/26237027 http://dx.doi.org/10.3390/jcm4010193 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Hodgetts, Stuart I.
Edel, Michael
Harvey, Alan R.
The State of Play with iPSCs and Spinal Cord Injury Models
title The State of Play with iPSCs and Spinal Cord Injury Models
title_full The State of Play with iPSCs and Spinal Cord Injury Models
title_fullStr The State of Play with iPSCs and Spinal Cord Injury Models
title_full_unstemmed The State of Play with iPSCs and Spinal Cord Injury Models
title_short The State of Play with iPSCs and Spinal Cord Injury Models
title_sort state of play with ipscs and spinal cord injury models
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470248/
https://www.ncbi.nlm.nih.gov/pubmed/26237027
http://dx.doi.org/10.3390/jcm4010193
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