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Neonatal blood stream infections in tertiary referral hospitals in Kurdistan, Iran
BACKGROUND: Bloodstream infection (BSI) is one of the most common causes of nosocomial infection in neonatal intensive care units (NICU). The aim of the present study was to determine bacterial agents and their susceptibility patterns to antibiotics and to investigate the risk factors associated wit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470359/ https://www.ncbi.nlm.nih.gov/pubmed/26051617 http://dx.doi.org/10.1186/s13052-015-0136-4 |
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author | Nikkhoo, Bahram Lahurpur, Fariba Delpisheh, Ali Rasouli, Mohammad Aziz Afkhamzadeh, Abdorrahim |
author_facet | Nikkhoo, Bahram Lahurpur, Fariba Delpisheh, Ali Rasouli, Mohammad Aziz Afkhamzadeh, Abdorrahim |
author_sort | Nikkhoo, Bahram |
collection | PubMed |
description | BACKGROUND: Bloodstream infection (BSI) is one of the most common causes of nosocomial infection in neonatal intensive care units (NICU). The aim of the present study was to determine bacterial agents and their susceptibility patterns to antibiotics and to investigate the risk factors associated with BSI. METHODS: This was a nested case–control study carried out from September 2009 to June 2010 in the NICU wards in Sanandaj hospitals western Iran. Cases were patients with BSI and controls were other patients who had negative blood culture. Bacteriologic diagnosis and antibiotic susceptibility pattern was performed based on the Edward & Ewings and the National Committee of Clinical Laboratory (NCCL) Standards. RESULTS: Of 472 patients who hospitalized in NICU, 6.4% had BSI (n = 30) including 17girls (56.7%) and 13 boys (43.3%). Enterobacter SPP was the predominant isolated bacteria from blood culture (36.7%). The maximum antibiotic resistance and sensitivity were observed by Tetracycline and Ciprofloxacin respectively. Risk factors associated with BSI were age ≤ 7 days (p = 0.001), previous antibiotic consumption (p = 0.013), and low birth weight (LBW), (p = 0.001). CONCLUSIONS: Gram negative bacteria and Entrobacter in particular are the most common pathogens. Improving prenatal health care, standards of infection control and choosing accurate antibiotics are recommended to avoid BSI in neonatal intensive care units. |
format | Online Article Text |
id | pubmed-4470359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44703592015-06-18 Neonatal blood stream infections in tertiary referral hospitals in Kurdistan, Iran Nikkhoo, Bahram Lahurpur, Fariba Delpisheh, Ali Rasouli, Mohammad Aziz Afkhamzadeh, Abdorrahim Ital J Pediatr Research BACKGROUND: Bloodstream infection (BSI) is one of the most common causes of nosocomial infection in neonatal intensive care units (NICU). The aim of the present study was to determine bacterial agents and their susceptibility patterns to antibiotics and to investigate the risk factors associated with BSI. METHODS: This was a nested case–control study carried out from September 2009 to June 2010 in the NICU wards in Sanandaj hospitals western Iran. Cases were patients with BSI and controls were other patients who had negative blood culture. Bacteriologic diagnosis and antibiotic susceptibility pattern was performed based on the Edward & Ewings and the National Committee of Clinical Laboratory (NCCL) Standards. RESULTS: Of 472 patients who hospitalized in NICU, 6.4% had BSI (n = 30) including 17girls (56.7%) and 13 boys (43.3%). Enterobacter SPP was the predominant isolated bacteria from blood culture (36.7%). The maximum antibiotic resistance and sensitivity were observed by Tetracycline and Ciprofloxacin respectively. Risk factors associated with BSI were age ≤ 7 days (p = 0.001), previous antibiotic consumption (p = 0.013), and low birth weight (LBW), (p = 0.001). CONCLUSIONS: Gram negative bacteria and Entrobacter in particular are the most common pathogens. Improving prenatal health care, standards of infection control and choosing accurate antibiotics are recommended to avoid BSI in neonatal intensive care units. BioMed Central 2015-06-09 /pmc/articles/PMC4470359/ /pubmed/26051617 http://dx.doi.org/10.1186/s13052-015-0136-4 Text en © Nikkhoo et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Nikkhoo, Bahram Lahurpur, Fariba Delpisheh, Ali Rasouli, Mohammad Aziz Afkhamzadeh, Abdorrahim Neonatal blood stream infections in tertiary referral hospitals in Kurdistan, Iran |
title | Neonatal blood stream infections in tertiary referral hospitals in Kurdistan, Iran |
title_full | Neonatal blood stream infections in tertiary referral hospitals in Kurdistan, Iran |
title_fullStr | Neonatal blood stream infections in tertiary referral hospitals in Kurdistan, Iran |
title_full_unstemmed | Neonatal blood stream infections in tertiary referral hospitals in Kurdistan, Iran |
title_short | Neonatal blood stream infections in tertiary referral hospitals in Kurdistan, Iran |
title_sort | neonatal blood stream infections in tertiary referral hospitals in kurdistan, iran |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470359/ https://www.ncbi.nlm.nih.gov/pubmed/26051617 http://dx.doi.org/10.1186/s13052-015-0136-4 |
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