Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPARγ and Fatty Acid Uptake

Transgenic mice (Tg) overexpressing human apolipoprotein D (H-apoD) in the brain are resistant to neurodegeneration. Despite the use of a neuron-specific promoter to generate the Tg mice, they expressed significant levels of H-apoD in both plasma and liver and they slowly develop hepatic steatosis a...

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Detalles Bibliográficos
Autores principales: Labrie, Marilyne, Lalonde, Simon, Najyb, Ouafa, Thiery, Maxime, Daneault, Caroline, Des Rosiers, Chrisitne, Rassart, Eric, Mounier, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470830/
https://www.ncbi.nlm.nih.gov/pubmed/26083030
http://dx.doi.org/10.1371/journal.pone.0130230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470830/
https://www.ncbi.nlm.nih.gov/pubmed/26083030
http://dx.doi.org/10.1371/journal.pone.0130230

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