SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

SerpinB2 (PAI-2), a member of the clade B family of serine protease inhibitors, is one of the most upregulated proteins following cellular stress. Originally described as an inhibitor of urokinase plasminogen activator, its predominant cytoplasmic localisation suggests an intracellular function. Ser...

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Detalles Bibliográficos
Autores principales: Lee, Jodi A., Yerbury, Justin J., Farrawell, Natalie, Shearer, Robert F., Constantinescu, Patrick, Hatters, Danny M., Schroder, Wayne A., Suhrbier, Andreas, Wilson, Mark R., Saunders, Darren N., Ranson, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470917/
https://www.ncbi.nlm.nih.gov/pubmed/26083412
http://dx.doi.org/10.1371/journal.pone.0130136

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