A Conserved Glycan in the C2 Domain of HIV-1 Envelope Acts as a Molecular Switch to Control X4 Utilization by Clonal Variants with Identical V3 Loops

Nearly all persons newly infected with HIV-1 harbor exclusively CCR5-using virus. CXCR4-using variants eventually arise in up to 50% of patients infected with subtypes B or D. This transition to efficient CXCR4 utilization is often co-incident with progression to AIDS. The basis for HIV-1’s initial...

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Detalles Bibliográficos
Autores principales: Lombardi, Francesca, Nakamura, Kyle J., Chen, Thomas, Sobrera, Edwin R., Tobin, Nicole H., Aldrovandi, Grace M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471078/
https://www.ncbi.nlm.nih.gov/pubmed/26083631
http://dx.doi.org/10.1371/journal.pone.0128116

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