Cargando…
Male Circumcision and STI Acquisition in Britain: Evidence from a National Probability Sample Survey
BACKGROUND: It is well-established that male circumcision reduces acquisition of HIV, herpes simplex virus 2, chancroid, and syphilis. However, the effect on the acquisition of non-ulcerative sexually transmitted infections (STIs) remains unclear. We examined the relationship between circumcision an...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471189/ https://www.ncbi.nlm.nih.gov/pubmed/26083250 http://dx.doi.org/10.1371/journal.pone.0130396 |
_version_ | 1782376863725780992 |
---|---|
author | Homfray, Virginia Tanton, Clare Miller, Robert F. Beddows, Simon Field, Nigel Sonnenberg, Pam Wellings, Kaye Panwar, Kavita Johnson, Anne M. Mercer, Catherine H. |
author_facet | Homfray, Virginia Tanton, Clare Miller, Robert F. Beddows, Simon Field, Nigel Sonnenberg, Pam Wellings, Kaye Panwar, Kavita Johnson, Anne M. Mercer, Catherine H. |
author_sort | Homfray, Virginia |
collection | PubMed |
description | BACKGROUND: It is well-established that male circumcision reduces acquisition of HIV, herpes simplex virus 2, chancroid, and syphilis. However, the effect on the acquisition of non-ulcerative sexually transmitted infections (STIs) remains unclear. We examined the relationship between circumcision and biological measures of three STIs: human papillomavirus (HPV), Chlamydia trachomatis and Mycoplasma genitalium. METHODS: A probability sample survey of 15,162 men and women aged 16-74 years (including 4,060 men aged 16-44 years) was carried out in Britain between 2010 and 2012. Participants completed a computer-assisted personal interview, including a computer-assisted self-interview, which asked about experience of STI diagnoses, and circumcision. Additionally, 1,850 urine samples from sexually-experienced men aged 16-44 years were collected and tested for STIs. Multivariable logistic regression was used to calculate adjusted odds ratios (AOR) to quantify associations between circumcision and i) self-reporting any STI diagnosis and ii) presence of STIs in urine, in men aged 16-44 years, adjusting for key socio-demographic and sexual behavioural factors. RESULTS: The prevalence of circumcision in sexually-experienced men aged 16-44 years was 17.4% (95%CI 16.0-19.0). There was no association between circumcision and reporting any previous STI diagnoses, and specifically previous chlamydia or genital warts. However, circumcised men were less likely to have any HPV type (AOR 0.26, 95% confidence interval (CI) 0.13-0.50) including high-risk HPV types (HPV-16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and/or 68) (AOR 0.14, 95% CI 0.05-0.40) detected in urine. CONCLUSIONS: Circumcised men had reduced odds of HPV detection in urine. These findings have implications for improving the precision of models of STI transmission in populations with different circumcision prevalence and in designing interventions to reduce STI acquisition. |
format | Online Article Text |
id | pubmed-4471189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44711892015-06-29 Male Circumcision and STI Acquisition in Britain: Evidence from a National Probability Sample Survey Homfray, Virginia Tanton, Clare Miller, Robert F. Beddows, Simon Field, Nigel Sonnenberg, Pam Wellings, Kaye Panwar, Kavita Johnson, Anne M. Mercer, Catherine H. PLoS One Research Article BACKGROUND: It is well-established that male circumcision reduces acquisition of HIV, herpes simplex virus 2, chancroid, and syphilis. However, the effect on the acquisition of non-ulcerative sexually transmitted infections (STIs) remains unclear. We examined the relationship between circumcision and biological measures of three STIs: human papillomavirus (HPV), Chlamydia trachomatis and Mycoplasma genitalium. METHODS: A probability sample survey of 15,162 men and women aged 16-74 years (including 4,060 men aged 16-44 years) was carried out in Britain between 2010 and 2012. Participants completed a computer-assisted personal interview, including a computer-assisted self-interview, which asked about experience of STI diagnoses, and circumcision. Additionally, 1,850 urine samples from sexually-experienced men aged 16-44 years were collected and tested for STIs. Multivariable logistic regression was used to calculate adjusted odds ratios (AOR) to quantify associations between circumcision and i) self-reporting any STI diagnosis and ii) presence of STIs in urine, in men aged 16-44 years, adjusting for key socio-demographic and sexual behavioural factors. RESULTS: The prevalence of circumcision in sexually-experienced men aged 16-44 years was 17.4% (95%CI 16.0-19.0). There was no association between circumcision and reporting any previous STI diagnoses, and specifically previous chlamydia or genital warts. However, circumcised men were less likely to have any HPV type (AOR 0.26, 95% confidence interval (CI) 0.13-0.50) including high-risk HPV types (HPV-16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and/or 68) (AOR 0.14, 95% CI 0.05-0.40) detected in urine. CONCLUSIONS: Circumcised men had reduced odds of HPV detection in urine. These findings have implications for improving the precision of models of STI transmission in populations with different circumcision prevalence and in designing interventions to reduce STI acquisition. Public Library of Science 2015-06-17 /pmc/articles/PMC4471189/ /pubmed/26083250 http://dx.doi.org/10.1371/journal.pone.0130396 Text en © 2015 Homfray et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Homfray, Virginia Tanton, Clare Miller, Robert F. Beddows, Simon Field, Nigel Sonnenberg, Pam Wellings, Kaye Panwar, Kavita Johnson, Anne M. Mercer, Catherine H. Male Circumcision and STI Acquisition in Britain: Evidence from a National Probability Sample Survey |
title | Male Circumcision and STI Acquisition in Britain: Evidence from a National Probability Sample Survey |
title_full | Male Circumcision and STI Acquisition in Britain: Evidence from a National Probability Sample Survey |
title_fullStr | Male Circumcision and STI Acquisition in Britain: Evidence from a National Probability Sample Survey |
title_full_unstemmed | Male Circumcision and STI Acquisition in Britain: Evidence from a National Probability Sample Survey |
title_short | Male Circumcision and STI Acquisition in Britain: Evidence from a National Probability Sample Survey |
title_sort | male circumcision and sti acquisition in britain: evidence from a national probability sample survey |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471189/ https://www.ncbi.nlm.nih.gov/pubmed/26083250 http://dx.doi.org/10.1371/journal.pone.0130396 |
work_keys_str_mv | AT homfrayvirginia malecircumcisionandstiacquisitioninbritainevidencefromanationalprobabilitysamplesurvey AT tantonclare malecircumcisionandstiacquisitioninbritainevidencefromanationalprobabilitysamplesurvey AT millerrobertf malecircumcisionandstiacquisitioninbritainevidencefromanationalprobabilitysamplesurvey AT beddowssimon malecircumcisionandstiacquisitioninbritainevidencefromanationalprobabilitysamplesurvey AT fieldnigel malecircumcisionandstiacquisitioninbritainevidencefromanationalprobabilitysamplesurvey AT sonnenbergpam malecircumcisionandstiacquisitioninbritainevidencefromanationalprobabilitysamplesurvey AT wellingskaye malecircumcisionandstiacquisitioninbritainevidencefromanationalprobabilitysamplesurvey AT panwarkavita malecircumcisionandstiacquisitioninbritainevidencefromanationalprobabilitysamplesurvey AT johnsonannem malecircumcisionandstiacquisitioninbritainevidencefromanationalprobabilitysamplesurvey AT mercercatherineh malecircumcisionandstiacquisitioninbritainevidencefromanationalprobabilitysamplesurvey |