Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene

In animal models, prenatal and postnatal stress is associated with elevated hypothalamic–pituitary axis (HPA) reactivity mediated via altered glucocorticoid receptor (GR) gene expression. Postnatal tactile stimulation is associated with reduced HPA reactivity mediated via increased GR gene expressio...

Descripción completa

Detalles Bibliográficos
Autores principales: Murgatroyd, C, Quinn, J P, Sharp, H M, Pickles, A, Hill, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471282/
https://www.ncbi.nlm.nih.gov/pubmed/25942041
http://dx.doi.org/10.1038/tp.2014.140
_version_ 1782376885663039488
author Murgatroyd, C
Quinn, J P
Sharp, H M
Pickles, A
Hill, J
author_facet Murgatroyd, C
Quinn, J P
Sharp, H M
Pickles, A
Hill, J
author_sort Murgatroyd, C
collection PubMed
description In animal models, prenatal and postnatal stress is associated with elevated hypothalamic–pituitary axis (HPA) reactivity mediated via altered glucocorticoid receptor (GR) gene expression. Postnatal tactile stimulation is associated with reduced HPA reactivity mediated via increased GR gene expression. In this first study in humans to examine the joint effects of prenatal and postnatal environmental exposures, we report that GR gene (NR3C1) 1-F promoter methylation in infants is elevated in the presence of increased maternal postnatal depression following low prenatal depression, and that this effect is reversed by self-reported stroking of the infants by their mothers over the first weeks of life.
format Online
Article
Text
id pubmed-4471282
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-44712822015-06-24 Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene Murgatroyd, C Quinn, J P Sharp, H M Pickles, A Hill, J Transl Psychiatry Original Article In animal models, prenatal and postnatal stress is associated with elevated hypothalamic–pituitary axis (HPA) reactivity mediated via altered glucocorticoid receptor (GR) gene expression. Postnatal tactile stimulation is associated with reduced HPA reactivity mediated via increased GR gene expression. In this first study in humans to examine the joint effects of prenatal and postnatal environmental exposures, we report that GR gene (NR3C1) 1-F promoter methylation in infants is elevated in the presence of increased maternal postnatal depression following low prenatal depression, and that this effect is reversed by self-reported stroking of the infants by their mothers over the first weeks of life. Nature Publishing Group 2015-05 2015-05-05 /pmc/articles/PMC4471282/ /pubmed/25942041 http://dx.doi.org/10.1038/tp.2014.140 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Murgatroyd, C
Quinn, J P
Sharp, H M
Pickles, A
Hill, J
Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene
title Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene
title_full Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene
title_fullStr Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene
title_full_unstemmed Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene
title_short Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene
title_sort effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471282/
https://www.ncbi.nlm.nih.gov/pubmed/25942041
http://dx.doi.org/10.1038/tp.2014.140
work_keys_str_mv AT murgatroydc effectsofprenatalandpostnataldepressionandmaternalstrokingattheglucocorticoidreceptorgene
AT quinnjp effectsofprenatalandpostnataldepressionandmaternalstrokingattheglucocorticoidreceptorgene
AT sharphm effectsofprenatalandpostnataldepressionandmaternalstrokingattheglucocorticoidreceptorgene
AT picklesa effectsofprenatalandpostnataldepressionandmaternalstrokingattheglucocorticoidreceptorgene
AT hillj effectsofprenatalandpostnataldepressionandmaternalstrokingattheglucocorticoidreceptorgene

Ejemplares similares