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Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia

Schizophrenia is increasingly thought of as a brain network or connectome disorder and is associated with neurodevelopmental processes. Previous studies have suggested the important role of anatomical distance in developing a connectome with optimized performance regarding both the cost and efficien...

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Autores principales: Jiang, L, Xu, Y, Zhu, X-T, Yang, Z, Li, H-J, Zuo, X-N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471290/
https://www.ncbi.nlm.nih.gov/pubmed/25966366
http://dx.doi.org/10.1038/tp.2015.59
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author Jiang, L
Xu, Y
Zhu, X-T
Yang, Z
Li, H-J
Zuo, X-N
author_facet Jiang, L
Xu, Y
Zhu, X-T
Yang, Z
Li, H-J
Zuo, X-N
author_sort Jiang, L
collection PubMed
description Schizophrenia is increasingly thought of as a brain network or connectome disorder and is associated with neurodevelopmental processes. Previous studies have suggested the important role of anatomical distance in developing a connectome with optimized performance regarding both the cost and efficiency of information processing. Distance-related disturbances during development have not been investigated in schizophrenia. To test the distance-related miswiring profiles of connectomes in schizophrenia, we acquired resting-state images from 20 adulthood-onset (AOS) and 26 early-onset schizophrenia (EOS) patients, as well as age-matched healthy controls. All patients were drug naive and had experienced their first psychotic episode. A novel threshold-free surface-based analytic framework was developed to examine local-to-remote functional connectivity profiles in both AOS and EOS patients. We observed consistent increases of local connectivity across both EOS and AOS patients in the right superior frontal gyrus, where the connectivity strength was correlated with a positive syndrome score in AOS patients. In contrast, EOS but not AOS patients exhibited reduced local connectivity within the right postcentral gyrus and the left middle occipital cortex. These regions' remote connectivity with their interhemispheric areas and brain network hubs was altered. Diagnosis–age interactions were detectable for both local and remote connectivity profiles. The functional covariance between local and remote homotopic connectivity was present in typically developing controls, but was absent in EOS patients. These findings suggest that a distance-dependent miswiring pattern may be one of the key neurodevelopmental features of the abnormal connectome organization in schizophrenia.
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spelling pubmed-44712902015-06-24 Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia Jiang, L Xu, Y Zhu, X-T Yang, Z Li, H-J Zuo, X-N Transl Psychiatry Original Article Schizophrenia is increasingly thought of as a brain network or connectome disorder and is associated with neurodevelopmental processes. Previous studies have suggested the important role of anatomical distance in developing a connectome with optimized performance regarding both the cost and efficiency of information processing. Distance-related disturbances during development have not been investigated in schizophrenia. To test the distance-related miswiring profiles of connectomes in schizophrenia, we acquired resting-state images from 20 adulthood-onset (AOS) and 26 early-onset schizophrenia (EOS) patients, as well as age-matched healthy controls. All patients were drug naive and had experienced their first psychotic episode. A novel threshold-free surface-based analytic framework was developed to examine local-to-remote functional connectivity profiles in both AOS and EOS patients. We observed consistent increases of local connectivity across both EOS and AOS patients in the right superior frontal gyrus, where the connectivity strength was correlated with a positive syndrome score in AOS patients. In contrast, EOS but not AOS patients exhibited reduced local connectivity within the right postcentral gyrus and the left middle occipital cortex. These regions' remote connectivity with their interhemispheric areas and brain network hubs was altered. Diagnosis–age interactions were detectable for both local and remote connectivity profiles. The functional covariance between local and remote homotopic connectivity was present in typically developing controls, but was absent in EOS patients. These findings suggest that a distance-dependent miswiring pattern may be one of the key neurodevelopmental features of the abnormal connectome organization in schizophrenia. Nature Publishing Group 2015-05 2015-05-12 /pmc/articles/PMC4471290/ /pubmed/25966366 http://dx.doi.org/10.1038/tp.2015.59 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Jiang, L
Xu, Y
Zhu, X-T
Yang, Z
Li, H-J
Zuo, X-N
Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia
title Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia
title_full Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia
title_fullStr Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia
title_full_unstemmed Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia
title_short Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia
title_sort local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471290/
https://www.ncbi.nlm.nih.gov/pubmed/25966366
http://dx.doi.org/10.1038/tp.2015.59
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