The positive effect on ketamine as a priming adjuvant in antidepressant treatment

Ketamine is an anesthetic with antidepressant properties. The rapid and lasting effect of ketamine observed in preclinical and clinical research makes it a promising therapeutic to improve current major depression (MD) treatment. Our work intended to evaluate whether the combined use of classic anti...

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Autores principales: Melo, A, Kokras, N, Dalla, C, Ferreira, C, Ventura-Silva, A P, Sousa, N, Pêgo, J M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471295/
https://www.ncbi.nlm.nih.gov/pubmed/26080090
http://dx.doi.org/10.1038/tp.2015.66
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author Melo, A
Kokras, N
Dalla, C
Ferreira, C
Ventura-Silva, A P
Sousa, N
Pêgo, J M
author_facet Melo, A
Kokras, N
Dalla, C
Ferreira, C
Ventura-Silva, A P
Sousa, N
Pêgo, J M
author_sort Melo, A
collection PubMed
description Ketamine is an anesthetic with antidepressant properties. The rapid and lasting effect of ketamine observed in preclinical and clinical research makes it a promising therapeutic to improve current major depression (MD) treatment. Our work intended to evaluate whether the combined use of classic antidepressants (imipramine or fluoxetine) and ketamine would improve the antidepressant response. Using an animal model of depressive-like behavior, we show that the addition of ketamine to antidepressants anticipates the behavioral response and accelerates the neuroplastic events when compared with the use of antidepressants alone. In conclusion, our results suggest the need for a reappraisal of the current pharmacological treatment of MD.
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spelling pubmed-44712952015-06-24 The positive effect on ketamine as a priming adjuvant in antidepressant treatment Melo, A Kokras, N Dalla, C Ferreira, C Ventura-Silva, A P Sousa, N Pêgo, J M Transl Psychiatry Original Article Ketamine is an anesthetic with antidepressant properties. The rapid and lasting effect of ketamine observed in preclinical and clinical research makes it a promising therapeutic to improve current major depression (MD) treatment. Our work intended to evaluate whether the combined use of classic antidepressants (imipramine or fluoxetine) and ketamine would improve the antidepressant response. Using an animal model of depressive-like behavior, we show that the addition of ketamine to antidepressants anticipates the behavioral response and accelerates the neuroplastic events when compared with the use of antidepressants alone. In conclusion, our results suggest the need for a reappraisal of the current pharmacological treatment of MD. Nature Publishing Group 2015-05 2015-05-26 /pmc/articles/PMC4471295/ /pubmed/26080090 http://dx.doi.org/10.1038/tp.2015.66 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Melo, A
Kokras, N
Dalla, C
Ferreira, C
Ventura-Silva, A P
Sousa, N
Pêgo, J M
The positive effect on ketamine as a priming adjuvant in antidepressant treatment
title The positive effect on ketamine as a priming adjuvant in antidepressant treatment
title_full The positive effect on ketamine as a priming adjuvant in antidepressant treatment
title_fullStr The positive effect on ketamine as a priming adjuvant in antidepressant treatment
title_full_unstemmed The positive effect on ketamine as a priming adjuvant in antidepressant treatment
title_short The positive effect on ketamine as a priming adjuvant in antidepressant treatment
title_sort positive effect on ketamine as a priming adjuvant in antidepressant treatment
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471295/
https://www.ncbi.nlm.nih.gov/pubmed/26080090
http://dx.doi.org/10.1038/tp.2015.66
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