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Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases
Emerging evidence reveals that various cytokines and tissue microenvironments contribute to liver inflammation and autoimmunity, and IL-17 family is one of highlights acknowledged. Although the implication of IL-17 family in most common autoimmune diseases (such as psoriasis, inflammatory bowel dise...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471389/ https://www.ncbi.nlm.nih.gov/pubmed/26146463 http://dx.doi.org/10.1155/2015/436450 |
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author | Zhang, Haiyan Bernuzzi, Francesca Lleo, Ana Ma, Xiong Invernizzi, Pietro |
author_facet | Zhang, Haiyan Bernuzzi, Francesca Lleo, Ana Ma, Xiong Invernizzi, Pietro |
author_sort | Zhang, Haiyan |
collection | PubMed |
description | Emerging evidence reveals that various cytokines and tissue microenvironments contribute to liver inflammation and autoimmunity, and IL-17 family is one of highlights acknowledged. Although the implication of IL-17 family in most common autoimmune diseases (such as psoriasis, inflammatory bowel disease, and rheumatoid arthritis) has been extensively characterized, the role of this critical family in pathophysiology of autoimmune liver diseases (AILD) still needs to be clarified. In the review, we look into the intriguing biology of IL-17 family and further dissect on the intricate role of IL-17-mediated pathway in AILD. Considering encouraging data from preclinical and clinical trials, IL-17 targeted therapy has shown promises in several certain autoimmune conditions. However, blocking IL-17-mediated pathway is just beginning, and more fully investigation and reflection are required. Taking together, targeting IL-17-mediated responses may open up new areas of potential clinical treatment for AILD. |
format | Online Article Text |
id | pubmed-4471389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44713892015-07-05 Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases Zhang, Haiyan Bernuzzi, Francesca Lleo, Ana Ma, Xiong Invernizzi, Pietro Mediators Inflamm Review Article Emerging evidence reveals that various cytokines and tissue microenvironments contribute to liver inflammation and autoimmunity, and IL-17 family is one of highlights acknowledged. Although the implication of IL-17 family in most common autoimmune diseases (such as psoriasis, inflammatory bowel disease, and rheumatoid arthritis) has been extensively characterized, the role of this critical family in pathophysiology of autoimmune liver diseases (AILD) still needs to be clarified. In the review, we look into the intriguing biology of IL-17 family and further dissect on the intricate role of IL-17-mediated pathway in AILD. Considering encouraging data from preclinical and clinical trials, IL-17 targeted therapy has shown promises in several certain autoimmune conditions. However, blocking IL-17-mediated pathway is just beginning, and more fully investigation and reflection are required. Taking together, targeting IL-17-mediated responses may open up new areas of potential clinical treatment for AILD. Hindawi Publishing Corporation 2015 2015-06-04 /pmc/articles/PMC4471389/ /pubmed/26146463 http://dx.doi.org/10.1155/2015/436450 Text en Copyright © 2015 Haiyan Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhang, Haiyan Bernuzzi, Francesca Lleo, Ana Ma, Xiong Invernizzi, Pietro Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases |
title | Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases |
title_full | Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases |
title_fullStr | Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases |
title_full_unstemmed | Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases |
title_short | Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases |
title_sort | therapeutic potential of il-17-mediated signaling pathway in autoimmune liver diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471389/ https://www.ncbi.nlm.nih.gov/pubmed/26146463 http://dx.doi.org/10.1155/2015/436450 |
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