Cargando…

Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases

Emerging evidence reveals that various cytokines and tissue microenvironments contribute to liver inflammation and autoimmunity, and IL-17 family is one of highlights acknowledged. Although the implication of IL-17 family in most common autoimmune diseases (such as psoriasis, inflammatory bowel dise...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Haiyan, Bernuzzi, Francesca, Lleo, Ana, Ma, Xiong, Invernizzi, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471389/
https://www.ncbi.nlm.nih.gov/pubmed/26146463
http://dx.doi.org/10.1155/2015/436450
_version_ 1782376911057453056
author Zhang, Haiyan
Bernuzzi, Francesca
Lleo, Ana
Ma, Xiong
Invernizzi, Pietro
author_facet Zhang, Haiyan
Bernuzzi, Francesca
Lleo, Ana
Ma, Xiong
Invernizzi, Pietro
author_sort Zhang, Haiyan
collection PubMed
description Emerging evidence reveals that various cytokines and tissue microenvironments contribute to liver inflammation and autoimmunity, and IL-17 family is one of highlights acknowledged. Although the implication of IL-17 family in most common autoimmune diseases (such as psoriasis, inflammatory bowel disease, and rheumatoid arthritis) has been extensively characterized, the role of this critical family in pathophysiology of autoimmune liver diseases (AILD) still needs to be clarified. In the review, we look into the intriguing biology of IL-17 family and further dissect on the intricate role of IL-17-mediated pathway in AILD. Considering encouraging data from preclinical and clinical trials, IL-17 targeted therapy has shown promises in several certain autoimmune conditions. However, blocking IL-17-mediated pathway is just beginning, and more fully investigation and reflection are required. Taking together, targeting IL-17-mediated responses may open up new areas of potential clinical treatment for AILD.
format Online
Article
Text
id pubmed-4471389
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-44713892015-07-05 Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases Zhang, Haiyan Bernuzzi, Francesca Lleo, Ana Ma, Xiong Invernizzi, Pietro Mediators Inflamm Review Article Emerging evidence reveals that various cytokines and tissue microenvironments contribute to liver inflammation and autoimmunity, and IL-17 family is one of highlights acknowledged. Although the implication of IL-17 family in most common autoimmune diseases (such as psoriasis, inflammatory bowel disease, and rheumatoid arthritis) has been extensively characterized, the role of this critical family in pathophysiology of autoimmune liver diseases (AILD) still needs to be clarified. In the review, we look into the intriguing biology of IL-17 family and further dissect on the intricate role of IL-17-mediated pathway in AILD. Considering encouraging data from preclinical and clinical trials, IL-17 targeted therapy has shown promises in several certain autoimmune conditions. However, blocking IL-17-mediated pathway is just beginning, and more fully investigation and reflection are required. Taking together, targeting IL-17-mediated responses may open up new areas of potential clinical treatment for AILD. Hindawi Publishing Corporation 2015 2015-06-04 /pmc/articles/PMC4471389/ /pubmed/26146463 http://dx.doi.org/10.1155/2015/436450 Text en Copyright © 2015 Haiyan Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Haiyan
Bernuzzi, Francesca
Lleo, Ana
Ma, Xiong
Invernizzi, Pietro
Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases
title Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases
title_full Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases
title_fullStr Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases
title_full_unstemmed Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases
title_short Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases
title_sort therapeutic potential of il-17-mediated signaling pathway in autoimmune liver diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471389/
https://www.ncbi.nlm.nih.gov/pubmed/26146463
http://dx.doi.org/10.1155/2015/436450
work_keys_str_mv AT zhanghaiyan therapeuticpotentialofil17mediatedsignalingpathwayinautoimmuneliverdiseases
AT bernuzzifrancesca therapeuticpotentialofil17mediatedsignalingpathwayinautoimmuneliverdiseases
AT lleoana therapeuticpotentialofil17mediatedsignalingpathwayinautoimmuneliverdiseases
AT maxiong therapeuticpotentialofil17mediatedsignalingpathwayinautoimmuneliverdiseases
AT invernizzipietro therapeuticpotentialofil17mediatedsignalingpathwayinautoimmuneliverdiseases