Covalent Modification of Bacteriophage T4 DNA Inhibits CRISPR-Cas9

The genomic DNAs of tailed bacteriophages are commonly modified by the attachment of chemical groups. Some forms of DNA modification are known to protect phage DNA from cleavage by restriction enzymes, but others are of unknown function. Recently, the CRISPR-Cas nuclease complexes were shown to medi...

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Detalles Bibliográficos
Autores principales: Bryson, Alexandra L., Hwang, Young, Sherrill-Mix, Scott, Wu, Gary D., Lewis, James D., Black, Lindsay, Clark, Tyson A., Bushman, Frederic D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471564/
https://www.ncbi.nlm.nih.gov/pubmed/26081634
http://dx.doi.org/10.1128/mBio.00648-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471564/
https://www.ncbi.nlm.nih.gov/pubmed/26081634
http://dx.doi.org/10.1128/mBio.00648-15

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