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Covalent Modification of Bacteriophage T4 DNA Inhibits CRISPR-Cas9
The genomic DNAs of tailed bacteriophages are commonly modified by the attachment of chemical groups. Some forms of DNA modification are known to protect phage DNA from cleavage by restriction enzymes, but others are of unknown function. Recently, the CRISPR-Cas nuclease complexes were shown to medi...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Microbiology
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471564/ https://www.ncbi.nlm.nih.gov/pubmed/26081634 http://dx.doi.org/10.1128/mBio.00648-15 |