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Monte Carlo-based dose calculation for (32)P patch source for superficial brachytherapy applications
Skin cancer treatment involving (32)P source is an easy, less expensive method of treatment limited to small and superficial lesions of approximately 1 mm deep. Bhabha Atomic Research Centre (BARC) has indigenously developed (32)P nafion-based patch source (1 cm × 1 cm) for treating skin cancer. For...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471639/ https://www.ncbi.nlm.nih.gov/pubmed/26150682 http://dx.doi.org/10.4103/0971-6203.152232 |
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author | Sahoo, Sridhar Palani, Selvam T. Saxena, S. K. Babu, D. A. R. Dash, A. |
author_facet | Sahoo, Sridhar Palani, Selvam T. Saxena, S. K. Babu, D. A. R. Dash, A. |
author_sort | Sahoo, Sridhar |
collection | PubMed |
description | Skin cancer treatment involving (32)P source is an easy, less expensive method of treatment limited to small and superficial lesions of approximately 1 mm deep. Bhabha Atomic Research Centre (BARC) has indigenously developed (32)P nafion-based patch source (1 cm × 1 cm) for treating skin cancer. For this source, the values of dose per unit activity at different depths including dose profiles in water are calculated using the EGSnrc-based Monte Carlo code system. For an initial activity of 1 Bq distributed in 1 cm(2) surface area of the source, the calculated central axis depth dose values are 3.62 × 10(-10) GyBq(-1) and 8.41 × 10(-11) GyBq(-1)at 0.0125 and 1 mm depths in water, respectively. Hence, the treatment time calculated for delivering therapeutic dose of 30 Gy at 1 mm depth along the central axis of the source involving 37 MBq activity is about 2.7 hrs. |
format | Online Article Text |
id | pubmed-4471639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44716392015-07-06 Monte Carlo-based dose calculation for (32)P patch source for superficial brachytherapy applications Sahoo, Sridhar Palani, Selvam T. Saxena, S. K. Babu, D. A. R. Dash, A. J Med Phys Original Article Skin cancer treatment involving (32)P source is an easy, less expensive method of treatment limited to small and superficial lesions of approximately 1 mm deep. Bhabha Atomic Research Centre (BARC) has indigenously developed (32)P nafion-based patch source (1 cm × 1 cm) for treating skin cancer. For this source, the values of dose per unit activity at different depths including dose profiles in water are calculated using the EGSnrc-based Monte Carlo code system. For an initial activity of 1 Bq distributed in 1 cm(2) surface area of the source, the calculated central axis depth dose values are 3.62 × 10(-10) GyBq(-1) and 8.41 × 10(-11) GyBq(-1)at 0.0125 and 1 mm depths in water, respectively. Hence, the treatment time calculated for delivering therapeutic dose of 30 Gy at 1 mm depth along the central axis of the source involving 37 MBq activity is about 2.7 hrs. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4471639/ /pubmed/26150682 http://dx.doi.org/10.4103/0971-6203.152232 Text en Copyright: © Journal of Medical Physics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sahoo, Sridhar Palani, Selvam T. Saxena, S. K. Babu, D. A. R. Dash, A. Monte Carlo-based dose calculation for (32)P patch source for superficial brachytherapy applications |
title | Monte Carlo-based dose calculation for (32)P patch source for superficial brachytherapy applications |
title_full | Monte Carlo-based dose calculation for (32)P patch source for superficial brachytherapy applications |
title_fullStr | Monte Carlo-based dose calculation for (32)P patch source for superficial brachytherapy applications |
title_full_unstemmed | Monte Carlo-based dose calculation for (32)P patch source for superficial brachytherapy applications |
title_short | Monte Carlo-based dose calculation for (32)P patch source for superficial brachytherapy applications |
title_sort | monte carlo-based dose calculation for (32)p patch source for superficial brachytherapy applications |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471639/ https://www.ncbi.nlm.nih.gov/pubmed/26150682 http://dx.doi.org/10.4103/0971-6203.152232 |
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