Aspartate-modified doxorubicin on its N-terminal increases drug accumulation in LAT1-overexpressing tumors

L-type amino acid transporter 1 (LAT1), overexpressed on the membrane of various tumor cells, is a potential target for tumor-targeting therapy. This study aimed to develop a LAT1-mediated chemotherapeutic agent. We screened doxorubicin modified by seven different large neutral amino acids. The aspa...

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Detalles Bibliográficos
Autores principales: Wu, Weidang, Dong, Yan, Gao, Jing, Gong, Min, Zhang, Xing, Kong, Weiling, Li, Yazhuo, Zeng, Yong, Si, Duanyun, Wei, Zihong, Ci, Xiaoyan, Jiang, Lixin, Li, Wei, Li, Quansheng, Yi, Xiulin, Liu, Changxiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471785/
https://www.ncbi.nlm.nih.gov/pubmed/25867020
http://dx.doi.org/10.1111/cas.12672

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