Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease

Macrophages can fuse to form osteoclasts in bone or multinucleate giant cells (MGCs) as part of the immune response. We use a systems genetics approach in rat macrophages to unravel their genetic determinants of multinucleation and investigate their role in both bone homeostasis and inflammatory dis...

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Detalles Bibliográficos
Autores principales: Kang, Heeseog, Kerloc’h, Audrey, Rotival, Maxime, Xu, Xiaoqing, Zhang, Qing, D’Souza, Zelpha, Kim, Michael, Scholz, Jodi Carlson, Ko, Jeong-Hun, Srivastava, Prashant K., Genzen, Jonathan R., Cui, Weiguo, Aitman, Timothy J., Game, Laurence, Melvin, James E., Hanidu, Adedayo, Dimock, Janice, Zheng, Jie, Souza, Donald, Behera, Aruna K., Nabozny, Gerald, Cook, H. Terence, Bassett, J.H. Duncan, Williams, Graham R., Li, Jun, Vignery, Agnès, Petretto, Enrico, Behmoaras, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471813/
https://www.ncbi.nlm.nih.gov/pubmed/25131209
http://dx.doi.org/10.1016/j.celrep.2014.07.032

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