Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo

Human intestinal organoids (HIOs) are a tissue culture model in which small intestine-like tissue is generated from pluripotent stem cells. By carrying out unsupervised hierarchical clustering of RNA-sequencing data, we demonstrate that HIOs most closely resemble human fetal intestine. We observed t...

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Detalles Bibliográficos
Autores principales: Finkbeiner, Stacy R., Hill, David R., Altheim, Christopher H., Dedhia, Priya H., Taylor, Matthew J., Tsai, Yu-Hwai, Chin, Alana M., Mahe, Maxime M., Watson, Carey L., Freeman, Jennifer J., Nattiv, Roy, Thomson, Matthew, Klein, Ophir D., Shroyer, Noah F., Helmrath, Michael A., Teitelbaum, Daniel H., Dempsey, Peter J., Spence, Jason R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471827/
https://www.ncbi.nlm.nih.gov/pubmed/26050928
http://dx.doi.org/10.1016/j.stemcr.2015.04.010

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