The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells

To ensure accurate genomic segregation, cells evolved the spindle assembly checkpoint (SAC), whose role in adult stem cells remains unknown. Inducible perturbation of a SAC kinase, Mps1, and its downstream effector, Mad2, in skeletal muscle stem cells shows the SAC to be critical for normal muscle g...

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Detalles Bibliográficos
Autores principales: Kollu, Swapna, Abou-Khalil, Rana, Shen, Carl, Brack, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471836/
https://www.ncbi.nlm.nih.gov/pubmed/25960061
http://dx.doi.org/10.1016/j.stemcr.2015.04.006

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