Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule

N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate. Here, we identify the molecular basis of the use...

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Detalles Bibliográficos
Autores principales: Vyklicky, Vojtech, Krausova, Barbora, Cerny, Jiri, Balik, Ales, Zapotocky, Martin, Novotny, Marian, Lichnerova, Katarina, Smejkalova, Tereza, Kaniakova, Martina, Korinek, Miloslav, Petrovic, Milos, Kacer, Petr, Horak, Martin, Chodounska, Hana, Vyklicky, Ladislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471902/
https://www.ncbi.nlm.nih.gov/pubmed/26086919
http://dx.doi.org/10.1038/srep10935

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